ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Determinants of posterior corneal optical densitometry and their relationship with endothelial morphology.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo investigate the relationship between corneal optical densitometry (COD) and endothelial morphologic parameters, and ocular aberrations, with particular emphasis on posterior corneal zones, and to explore associations between COD and corneal optical aberrations.
methodsThis retrospective cross-sectional study included 108 eyes of 55 subjects. Corneal densitometry was assessed using Scheimpflug tomography, and endothelial cell density (ECD) and morphologic parameters, including coefficient of variation (CV), hexagonality (HEX), and cell-area indices, were obtained using non-contact specular microscopy. Associations between COD and endothelial parameters were evaluated using linear mixed-effects models with subject-specific random intercepts to account for inter-eye correlation. Age, sex, central corneal thickness (CCT), and relevant endothelial variables were included as fixed effects.
resultsAge was independently associated with global COD (β = 0.299; 95% CI, 0.220-0.378; P < 0.001) and posterior COD in the 0-2 mm (β = 0.079; 95% CI, 0.042-0.116), 2-6 mm (β = 0.119; 95% CI, 0.077-0.161), and 6-10 mm zones (β = 0.370; 95% CI, 0.277-0.463; all P < 0.001). ECD was not independently associated with global or posterior COD (all P > 0.05). Exploratory analyses showed inverse associations of maximum cell area with global COD (β=-0.0014; P = 0.034) and posterior 6-10 mm COD (β=-0.0026; P = 0.008), while CV was inversely associated with posterior 6-10 mm COD (β=-0.097; P = 0.047). These morphologic associations were not retained in the one-eye sensitivity analysis. No consistent association was identified between COD and optical aberrations.
conclusionsAge was the most consistent determinant of global and posterior COD, whereas ECD was not independently associated with densitometry. Selected endothelial morphometric parameters showed exploratory zone-specific associations, although these were not robust in the one-eye sensitivity analysis. COD may therefore provide information distinct from ECD; however, longitudinal studies are needed to determine the clinical significance of posterior COD in endothelial assessment.
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