Evidence map›Paper›PMID 42841977›Full record

ArticleEuropean journal of nutrition2026

Plasma biomarkers of vitamin B6 homeostasis and the risk of stroke in individuals with type 2 diabetes: a nested case-control study.

Yi Ding, Xujia Lu, Yulong Fan, Ning Zhang, Zhengyuan Zhou, Yang Geng, Xiaohong Zhu, Yalong Pei, Xinmei Lu, Yan Borné and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yi Ding *Jiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College, Suzhou, China.
Xujia Lu *Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yulong FanDepartment of Epidemiology and Biostatistics, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Ning ZhangDepartment of Chronic Disease Control and Prevention, Changshu Center for Disease Control and Prevention, Suzhou, China.
Zhengyuan ZhouDepartment of Chronic Disease Control and Prevention, Changshu Center for Disease Control and Prevention, Suzhou, China.
Yang GengDepartment of Epidemiology and Biostatistics, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Xiaohong ZhuSuzhou Centers for Disease Control and Prevention, Suzhou, Jiangsu, China.
Yalong PeiDepartment of Epidemiology and Biostatistics, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Xinmei LuDepartment of Epidemiology and Biostatistics, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Yan BornéDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Shujun GuDepartment of Chronic Disease Control and Prevention, Changshu Center for Disease Control and Prevention, Suzhou, China. 18862108157@163.com.
Chaofu KeDepartment of Epidemiology and Biostatistics, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China. cfke@suda.edu.cn.ORCID http://orcid.org/0000-0003-3188-4307

Funding

A Project Funded by Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) No grant numberJiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control CDSGK1202502National Natural Science Foundation of China 81703316Research on Key Technologies for the Prevention and Control of Major Diseases and Infectious Diseases in Suzhou GWZX202101Research on Key Technologies for the Prevention and Control of Major Diseases and Infectious Diseases in Suzhou GWZX202304the Youth Science and Technology Talent Support Program of Jiangsu Province JSTJ-2023-WJ005
6 · The paper itself

Abstract

purposeVitamin B6 metabolism is implicated in chronic inflammation and insulin resistance, two important factors influencing stroke and type 2 diabetes, respectively. This study aimed to investigate the prospective associations of multiple plasma biomarkers of vitamin B6 homeostasis, i.e. 4-pyridoxic acid (PA), pyridoxal (PL), pyridoxal-5'-phosphate (PLP) and the ratio of PA:[PL+PLP] (PAr), with the risk of stroke in individuals with type 2 diabetes, and evaluate the predictive performance of these markers.

methodsThis nested case-control study involved individuals with type 2 diabetes, 967 cases of incident stroke and 967 matched controls without stroke from a prospective Chinese cohort. Plasma levels of PA, PL and PLP were measured using a targeted metabolomics approach. The net reclassification index (NRI) was calculated to assess the predictive performance of PA, PL, PLP and PAr.

resultsCompared with individuals with the lowest quartile of plasma PAr, the odds ratio (OR) and 95% CI was 2.915 (2.072-4.101) for the highest quartile. By contrast, the ORs (95% CIs) of the highest quartile versus the lowest were 0.577 (0.432-0.771) for PL, 0.652 (0.488-0.871) for PLP, and 1.232 (0.897-1.692) for PA, respectively. In addition, adding plasma levels of PAr, PL and PLP offered incremental reclassification ability for incident stroke beyond the conventional risk factors. The greatest reclassification ability improvement was observed for the combination of PAr, PL and PLP (NRI: 0.482, 95% CI: 0.395-0.568).

conclusionsPlasma levels of PAr, PL and PLP were significantly associated with the risk of incident stroke and provided incremental ability for the risk prediction of stroke in individuals with type 2 diabetes.

Indexed as

Diabetes Mellitus, Type 2StrokeVitamin B 6AgedBiomarkersCase-Control StudiesChinaFemaleHomeostasisHumansMaleMiddle AgedProspective StudiesPyridoxalPyridoxal PhosphatePyridoxic AcidBiomarkersPyridoxalPyridoxal PhosphatePyridoxic AcidVitamin B 6BiomarkerStrokeType 2 diabetesVitamin B6

Identifiers

PMID42841977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.