ReviewVirchows Archiv : an international journal of pathology2026
Gastric dysplasia: an integrated classification of surface epithelium-derived precursor lesions.
Review in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric dysplasia comprises a heterogeneous group of non-invasive epithelial neoplasms with distinct clinicopathological and biological characteristics. This review focuses on surface epithelium-derived lesions, including intestinal-type, foveolar-type, and serrated dysplasia/adenoma. Conventional low-grade intestinal-type dysplasias/adenomas arise mainly in atrophic and metaplastic mucosa associated with Helicobacter pylori infection or, much less frequently, autoimmune gastritis. Small, pale, flat-elevated lesions with orderly small-intestinal differentiation generally behave indolently, whereas large size, redness, depression, nodularity, high-grade histology, and abnormal p53 expression are associated with an increased risk of progression. Foveolar-type dysplasia/adenoma is particularly heterogeneous. Flat-elevated foveolar-type adenoma, raspberry-type adenoma, and dysplasia arising in fundic gland polyps represent distinct dysplasia subtypes with indolent behavior. In contrast, other foveolar-type lesions are biologically heterogeneous; some are associated with microsatellite instability-high or Epstein-Barr virus-associated gastric carcinoma, whereas others may represent the superficial component of poorly differentiated or deceptively well-differentiated adenocarcinoma. Gastric serrated dysplasia is rare but is frequently associated with invasive carcinoma and should be regarded as a high-risk lesion requiring complete resection. Accurate diagnosis therefore requires integration of histological findings with endoscopic appearance and the background gastric mucosa. The principal role of pathological diagnosis is to distinguish dysplastic lesions with indolent behavior from those carrying a non-negligible risk of progression to invasive carcinoma, thereby guiding optimal clinical management.
Indexed as
Identifiers
42841970What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.