Evidence map›Paper›PMID 42841917›Full record

ArticleDiabetologia2026

CGM-derived disposition index estimates beta cell function in individuals with islet autoimmunity who do not require insulin treatment; changes in the disposition index precede changes identified by CGM metrics 1 year later.

Hadija Marchiori, Michele Schiavon, Eileen Tichy, Michele Alguard, Marcia DeSousa, Simone Del Favero, Jason L Gaglia, Jennifer L Sherr, Chiara Dalla Man, Alfonso Galderisi

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Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Hadija MarchioriDepartment of Pediatrics, Pediatric Endocrinology and Diabetes, Yale University, New Haven, CT, USA.
Michele SchiavonDepartment of Information Engineering, University of Padova, Padova, Italy.
Eileen TichyDepartment of Pediatrics, Pediatric Endocrinology and Diabetes, Yale University, New Haven, CT, USA.
Michele AlguardDepartment of Pediatrics, Pediatric Endocrinology and Diabetes, Yale University, New Haven, CT, USA.
Marcia DeSousaDepartment of Pediatrics, Pediatric Endocrinology and Diabetes, Yale University, New Haven, CT, USA.
Simone Del FaveroDepartment of Information Engineering, University of Padova, Padova, Italy.
Jason L GagliaJoslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Jennifer L Sherr *Department of Pediatrics, Pediatric Endocrinology and Diabetes, Yale University, New Haven, CT, USA.
Chiara Dalla Man *Department of Information Engineering, University of Padova, Padova, Italy. chiara.dallaman@unipd.it.
Alfonso Galderisi *Department of Pediatrics, Pediatric Endocrinology and Diabetes, Yale University, New Haven, CT, USA. alfonso.galderisi@yale.edu.

Funding

Juvenile Diabetes Research Foundation International 3-SRA-2022-1186-S-B
6 · The paper itself

Abstract

aims/hypothesisMonitoring of beta cell function in individuals with islet autoimmunity who do not require insulin treatment (preclinical type 1 diabetes) is normally done via OGTTs, posing major challenges given the invasiveness of the test. Here, we validated a disposition index (DI) derived from continuous glucose monitoring (CGM) metrics (DI

methodsParticipants underwent a 3 h 10-point OGTT with measurement of glucose, insulin and C-peptide while wearing a blinded CGM. The sensor was started 24 h prior to the OGTT. DI

resultsTwenty-four participants (median age 16.8 years [IQR 13.5-27.7] ) were enrolled, of whom 18 completed both the OGTT (ten with pre-stage 1, seven with stage 1 and one with stage 3a type 1 diabetes) and CGM at baseline, and had repeat CGM 1 year later. The baseline DI CONCLUSIONS/

interpretationBeta cell function can be estimated using CGM during a glucose load. DI

Indexed as

Beta cell functionCGMContinuous glucose monitoringDigital biomarkersModel identificationPreclinical T1D; Stage 1 T1DStage 2 T1DType 1 diabetes

Identifiers

PMID42841917

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.