Evidence map›Paper›PMID 42841858›Full record

ArticleAIDS education and prevention : official publication of the International Society for AIDS Education2026

Longitudinal Risk Factors for Incident Lung Cancer Among a Mixed HIV Serostatus Cohort of Sexual Minority Men in the United States.

Yuhang Qian, Zuo-Feng Zhang, Warren Scott Comulada, Marco A Hidalgo, Sung-Jae Lee, M Reuel Friedman, Frank J Palella, Michael W Plankey, Gypsyamber D'Souza, Roger Detels and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS education and prevention : official publication of the International Society for AIDS Education, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuhang QianThe Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California.
Zuo-Feng ZhangThe Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California.
Warren Scott ComuladaThe Department of Psychiatry and Biobehavioral Sciences, UCLA Geffen School of Medicine, Los Angeles.
Marco A HidalgoThe Department of Medicine, UCLA Geffen School of Medicine, Los Angeles.
Sung-Jae LeeThe Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California.
M Reuel FriedmanThe Department of Urban-Global Public Health, Rutgers, the State University of New Jersey, New Brunswick, New Jersey.
Frank J PalellaThe Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Michael W PlankeyThe Department of Medicine, Division of General Internal Medicine, Georgetown University, Washington, D.C.
Gypsyamber D'SouzaThe Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Roger DetelsThe Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California.
Matthew J MimiagaThe Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALLAN E RODRIGUEZ · 2007 to 2026
$33.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
NCATS NIH HHS KL2 TR001432NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NCI NIH HHS R25 CA112383NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI073961NIAID NIH HHS P30 AI124414NIMH NIH HHS P30 MH058107NIMH NIH HHS P30 MH116867
6 · The paper itself

Abstract

To examine how the co-occurrence of behavioral and psychosocial factors (depression, cigarette smoking, heavy alcohol use, and polydrug use) is associated with lung cancer incidence, we included 3,554 sexual minority men (SMM) from the Multicenter AIDS Cohort Study (MACS), 1996-2022, with assessments every 6 months. We used Cox proportional hazards models to examine the cumulative relationships of these factors with lung cancer incidence. We identified a positive dose-response relationship between the number of these factors and lung cancer incidence. Compared to men with no factors, those with two (aHR= 3.80, 95% Cl [1.46, 9.86]) and three or more (aHR = 8.33, 95% Cl [2.20, 31.60]) had increased lungcancer risk. Men living with HIV were more affected by these factors than men without HIV. Our findings highlight the need for prevention and treatment for depression and substance use when assessing lung cancer risk among SMM, which may inform strategies to reduce lung cancer incidence.

Indexed as

HIV InfectionsHIV SeropositivityHomosexuality, MaleLung NeoplasmsSexual and Gender MinoritiesAdultAlcohol DrinkingCohort StudiesDepressionHumansIncidenceLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsRisk Factorsbehavioral and psychosocial factorsHIVlung cancer incidencesexual minority men

Identifiers

PMID42841858
PMCPMC13676826

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.