Evidence map›Paper›PMID 42841652›Full record

Trial reportGut microbes2026

Synbiotic supplementation leads to gut microbiome communities with functional capacity linked to better brain white matter development in preterm infants.

Anna Voulgari-Kokota, Els Janson, Ineke Heikamp de Jong, Jan Knol, Ruurd van Elburg, Niek E van der Aa, Lisa M Hortensius, Jeroen Dudink, Caroline G M de Theije, Lidewij Schipper and 21 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Anna Voulgari-KokotaLaboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.
Els JansonDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Ineke Heikamp de JongLaboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.
Jan KnolDanone Research & Innovation, Utrecht, The Netherlands.ORCID 0000-0002-2103-5961
Ruurd van ElburgDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Niek E van der AaDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Lisa M HortensiusDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Jeroen DudinkDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Caroline G M de TheijeDepartment for Developmental Origins of Disease, University Medical Center Utrecht Brain Center and Wilhelmina Children's Hospital, Utrecht University, Utrecht, The Netherlands.
Lidewij SchipperDanone Research & Innovation, Utrecht, The Netherlands.
Marta KoziorDanone Research & Innovation, Utrecht, The Netherlands.
Monique van de LagemaatDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Floris GroenendaalDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Frank van BelDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Annemieke Wildt-GrootendorstDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Sandra Drost-VerhoefDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Annelies HenninkDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Charlie C ObiharaDepartment of Pediatrics, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands.
Jacqueline L A M van Hillegersberg-SchilderDepartment of Pediatrics, Sint Antonius Hospital, Nieuwegein, The Netherlands.
Carin M DasselDepartment of Pediatrics, Deventer Hospital, Deventer, The Netherlands.
Johanna H OudshoornDepartment of Pediatrics, Gelre Hospital, Apeldoorn, The Netherlands.
Clemens B MeijssenDepartment of Pediatrics, Meander Medical Centre, Amersfoort, The Netherlands.
Inge P de BoerDepartment of Pediatrics, Diakonessenhuis, Utrecht, The Netherlands.
Károly E IllyDepartment of Pediatrics, Hospital Rivierenland, Tiel, The Netherlands.
Nathalie ClaessensDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Max A ViergeverImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
Ivana IsgumImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
Sudarshan ShettyDanone Research & Innovation, Utrecht, The Netherlands.
Harm WopereisDanone Research & Innovation, Utrecht, The Netherlands.ORCID 0000-0002-2103-1442
Manon BendersDepartment of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Clara BelzerLaboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.ORCID 0000-0001-6922-836X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preterm birth, a major cause of brain injury, is often linked to dysregulated gut microbiome development. This association underscores microbial metabolic function as a modifiable target to support neurodevelopment. In this secondary analysis of data derived from a randomized controlled trial (Trial Registration: ISRCTN96620855), we tested whether daily nutritional supplementation with

Indexed as

BrainGastrointestinal MicrobiomeInfant, PrematureSynbioticsWhite MatterBifidobacterium breveDietary SupplementsFemaleGlutamineHumansInfantInfant, NewbornMagnetic Resonance ImagingMaleNeurodevelopmentOligosaccharidesGlutamineOligosaccharidesBifidobacterium brevebrain maturationgut–brainprematuritypreterm infantspreterm microbiomeProbiotics

Identifiers

PMID42841652
PMCPMC13656805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.