Evidence map›Paper›PMID 42841558›Full record

ReviewJACC. Asia2026

Elevated Lipoprotein(a) in Asian Populations and its Implications for Cardiovascular Disease.

Matthew D'Amore, Wann Jia Loh, David Tak Wai Lui, Hayato Tada, Rungroj Krittayaphong, Khalida Soomro, Wael Almahmeed, Thushara Matthias, Kian Keong Poh, Jian Jun Li and 8 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Matthew D'AmoreNorthern Health, Epping, Australia.
Wann Jia LohDepartment of Endocrinology, Changi General Hospital, Singapore, Singapore.
David Tak Wai LuiDivision of Endocrinology and Metabolism, Department of Medicine, School of Clinical Medicine, Li KaShing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Queen Mary Hospital, Hong Kong SAR, China.
Hayato TadaDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University Kanazawa, Kanazawa, Japan.
Rungroj KrittayaphongDepartment of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Khalida SoomroZiauddin University Hospital, North Nazimabad, Karachi, Pakistan.
Wael AlmahmeedCleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Thushara MatthiasFaculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.
Kian Keong PohNational University Heart Center Singapore, Singapore, Singapore.
Jian Jun LiFuwai Hospital, Beijing, China.
Julie ButtersVictorian Heart Institute, Monash University, Clayton, Australia.
Yu KataokaNational Cerebral and Cardiovascular Center, Osaka, Japan.
Mayank DalakotiNational University Heart Center Singapore, Singapore, Singapore.
Jamshed J DalalKokilaben Hospital, Andheri West, Mumbai, India.
Adam NelsonDepartment of Cardiology, Royal Adelaide Hospital, Adelaide, Australia.
Salim S ViraniSection of Cardiology, Department of Medicine, Aga Khan University, Karachi, Pakistan; Department of Population Health, Aga Khan University, Nairobi, Kenya.
Stephen J NichollsVictorian Heart Institute, Monash University, Clayton, Australia.
Richard C O'BrienDepartments of Medical Education and Medicine, Melbourne Medical School, University of Melbourne, Parkville, Australia. Electronic address: robrien@unimelb.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated lipoprotein (a) (Lp[a]) is becoming increasingly recognized as a cardiovascular disease risk factor. The relationship of Lp(a) to cardiovascular disease is well characterized in European populations; however, data are lacking in the Asian region. In this scoping review, we aimed to characterize the distribution and prevalence of elevated Lp(a) in the Asian region and its relationship to coronary artery disease, cerebrovascular disease, and peripheral vascular disease. Thirty-one Asian studies met the inclusion criteria and were compared with 6 representative European studies. The greatest representation was in Chinese populations, with much less representation of Japanese, Thai, Indian, and other groups. Levels of Lp(a) in healthy Asian populations were generally lower than in Europid (Caucasian) populations; however, these levels remain lower than those reported in European literature. Within Asian populations, elevated Lp(a) was universally associated with increased risk of coronary artery disease and peripheral vascular disease. The relationship with stroke was less clear.

Indexed as

Asiacardiovascular diseaselipoprotein (a)

Identifiers

PMID42841558
PMCPMC13654413

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.