Evidence map›Paper›PMID 42841441›Full record

SynthesisApplied psychology. Health and well-being2026

Digital health interventions for psychological and cognitive care in cancer patients and caregivers: A RE-AIM-based systematic review.

Melissa Heifez, Laura Ciria-Suarez, Sara Martín-Parra, Ilaria Durosini, Dario Monzani, Veronica Coppini, Maria Vittoria Ferrari, Mareike Rutenkröger, Marie Lange, Nikolina Dodlek and 7 more

Abstract readSystematic Review
In one paragraph

Synthesis in Applied psychology. Health and well-being, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Melissa HeifezICOnnecta't Digital Health Program, Catalan Institute of Oncology, Hospitalet del Llobregat, Spain.ORCID https://orcid.org/0009-0000-1047-3993
Laura Ciria-SuarezICOnnecta't Digital Health Program, Catalan Institute of Oncology, Hospitalet del Llobregat, Spain.ORCID https://orcid.org/0000-0002-1388-6686
Sara Martín-ParraICOnnecta't Digital Health Program, Catalan Institute of Oncology, Hospitalet del Llobregat, Spain.ORCID https://orcid.org/0009-0008-4675-8358
Ilaria DurosiniApplied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID https://orcid.org/0000-0002-8500-2675
Dario MonzaniApplied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID https://orcid.org/0000-0001-9544-2933
Veronica CoppiniApplied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID https://orcid.org/0009-0003-8238-2101
Maria Vittoria FerrariApplied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID https://orcid.org/0009-0009-0947-8020
Mareike RutenkrögerDepartment of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-2122-6661
Marie LangeClinical Research Department, UNICANCER, Centre François Baclesse, Caen, France.ORCID https://orcid.org/0000-0002-1749-2713
Nikolina DodlekDepartment of Nursing, Cyprus University of Technology, Limassol, Cyprus.ORCID https://orcid.org/0000-0002-0534-721X
Lotte van der WeijstEuropean Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium.ORCID https://orcid.org/0000-0001-8658-1894
Andreas CharalambousDepartment of Nursing, Cyprus University of Technology, Limassol, Cyprus.ORCID https://orcid.org/0000-0003-4050-031X
Marta Perez-CampdepadrósDepartment of Child and Adolescent Mental Health and Pediatric Cancer Centre (PCCB), Hospital Sant Joan de Déu, Barcelona, Spain.ORCID https://orcid.org/0009-0006-2869-224X
Derek ClougherDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.ORCID https://orcid.org/0000-0001-7631-3845
Miguel Angel OrregoICOnnecta't Digital Health Program, Catalan Institute of Oncology, Hospitalet del Llobregat, Spain.
Gabriella PravettoniApplied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID https://orcid.org/0000-0002-4843-4663
Cristian Ochoa-ArnedoICOnnecta't Digital Health Program, Catalan Institute of Oncology, Hospitalet del Llobregat, Spain.ORCID https://orcid.org/0000-0002-4508-0951

Funding

Carlos III Health Institute (Instituto de Salud Carlos III) PI22/01255Emergent Agència d'Ajuts Universitaris i de Recerca of the Generalitat de Catalunya 2021 SGR 01003European Regional Development FundEuropean Union's EU4Health Programme 101161236
6 · The paper itself

Abstract

Beyond physical challenges, cancer can cause psychological and cognitive challenges for patients, caregivers, and family members. Digital health interventions show promise in addressing these issues. However, evidence on their applicability in daily cancer care is limited. The objective of this systematic review is to evaluate the internal and external validity of digital health interventions targeting psychological and cognitive impairments in cancer patients, caregivers, and family members, using the RE-AIM framework. This systematic review was conducted following the PRISMA guidelines, using Pubmed/MEDLINE, Scopus, and PsychINFO databases. Data were extracted using data forms based on the RE-AIM framework. The methodological quality was assessed using the Quality Assessment Tool for Quantitative Studies (QATQS). A total of 191 studies involving 29.907 patients and caregivers met the inclusion criteria. Included studies were randomized controlled trials and nonrandomized studies of interventions related to digital health, using an online or hybrid format. The reach, implementation, and effectiveness domains were most frequently reported, while adoption and maintenance were the most unreported domains within the RE-AIM framework. Despite reporting on reach, effectiveness, and implementation, limited data on external validity restricts the impact and scalability of digital health interventions in cancer care. Future research should endeavor to address current challenges and improve the use of digital health interventions in cancer care.

Indexed as

CaregiversCognitive DysfunctionNeoplasmsDigital HealthHumanscancercognitive functiondigital healthimplementation evaluationpsychological impairmentRE‐AIM

Identifiers

PMID42841441
PMCPMC13643931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.