ReviewDementia & neuropsychologia2026
Impact of metformin use on neurocognitive functions in older people: a systematic review and meta-analysis.
Review in Dementia & neuropsychologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Metformin is a widely prescribed drug for managing diabetes mellitus. Recent studies have investigated its potential effects on cognitive function in adults aged 60 years and older, a population that is steadily increasing and often exhibits cognitive impairments associated with aging and other chronic conditions. Objective: This study aimed to evaluate the impact of metformin use on cognitive functions in older adults through a meta-analysis. Methods: A systematic review and meta-analysis were conducted in accordance with the PRISMA guidelines, utilizing the Embase, LILACS, PubMed, Scopus, and Web of Science databases. The review protocol was registered in PROSPERO (CRD42024624045). Results: Thirteen articles met the eligibility criteria for inclusion in this systematic review, of which five provided sufficient data for the meta-analysis. The findings indicate that metformin has a small but positive effect on overall cognitive function in older adults. Additionally, the meta-analysis demonstrated low heterogeneity (49.6%) and a low risk of bias (p>0.05). Conclusion: The results suggest that metformin may have a protective effect on the overall cognitive function of older adults, in addition to its well-established metabolic benefits.
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