Evidence map›Paper›PMID 42841128›Full record

ArticleFrontiers in toxicology2026

Integrated transcriptomic and metabolomic ecotoxicity assessment of earthworms exposed to ZnO and Mn-doped ZnO nanomaterials.

Henk J van Lingen, Paraskevi Zagana, Changlin Ke, Edoardo Saccenti, Marta Baccaro, Maria I Klapa, Zoi G Lada, Nico W van den Brink, Maria Suarez-Diez

Abstract read
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Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Henk J van LingenLaboratory of Systems & Synthetic Biology, Wageningen University & Research, Wageningen, Netherlands.
Paraskevi ZaganaMetabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas (FORTH/ICE-HT), Patras, Greece.
Changlin KeLaboratory of Systems & Synthetic Biology, Wageningen University & Research, Wageningen, Netherlands.
Edoardo SaccentiLaboratory of Systems & Synthetic Biology, Wageningen University & Research, Wageningen, Netherlands.
Marta BaccaroDivision of Toxicology, Wageningen University & Research, Wageningen, Netherlands.
Maria I KlapaMetabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas (FORTH/ICE-HT), Patras, Greece.
Zoi G LadaLaboratory of Applied Molecular Spectroscopy, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas (FORTH/ICE-HT), Patras, Greece.
Nico W van den BrinkDivision of Toxicology, Wageningen University & Research, Wageningen, Netherlands.
Maria Suarez-DiezLaboratory of Systems & Synthetic Biology, Wageningen University & Research, Wageningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Zinc oxide (ZnO)-containing nanomaterials may elicit toxic responses in environmental organisms such as earthworms. In this study, we investigate the time-dependent gene expression and metabolomic response in earthworms exposed to ZnO and Mn-doped ZnO (ZnO:Mn) nanomaterials (both at 850 mg/kg soil) and MnCl Methods: Earthworms were exposed to ZnO nanomaterial (850 mg/kg soil) for 2, 3, 4, or 7 days, to ZnO:Mn nanomaterial (850 mg/kg soil) for 2, 4, 7, or 14 days, and to MnCl Results and Discussion: Strong differential gene expression was observed after 4 and 2 days of exposure to ZnO and ZnO:Mn, respectively. Moderate differential gene expression was observed after 14 days of exposure to ZnO:Mn and MnCl

Indexed as

enrichment analysisgene expressioninvertebratemetabolomemode of actionmulticomponent nanomaterial

Identifiers

PMID42841128
PMCPMC13641736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.