Evidence map›Paper›PMID 42841094›Full record

ArticleISME communications2026

Quorum-sensing microbial dark matter enables core functions in wastewater microbiomes.

Qiuju Liu, Han Su, Sai Gong, Ying Jin, Yingzheng Fan, Mengxiong Wu, Jianhua Guo, Xinkun Ren, Jinfeng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ISME communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiuju LiuState Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing 210023, Jiangsu, China.
Han SuState Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing 210023, Jiangsu, China.
Sai GongState Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing 210023, Jiangsu, China.
Ying JinState Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing 210023, Jiangsu, China.ORCID https://orcid.org/0000-0002-7288-2407
Yingzheng FanState Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing 210023, Jiangsu, China.
Mengxiong WuState Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing 210023, Jiangsu, China.
Jianhua GuoAustralian Centre for Water and Environmental Biotechnology (ACWEB, Formerly AWMC), The University of Queensland, Brisbane, St. Lucia, Queensland, 4072, Australia.
Xinkun RenCollege of Engineering and Applied Sciences, Nanjing University, Nanjing 210023, Jiangsu, China.
Jinfeng WangState Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing 210023, Jiangsu, China.ORCID https://orcid.org/0000-0001-9001-1413

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quorum-sensing bacteria (QSB) play a crucial role in coordinating microbial activities in activated sludge. However, our knowledge is primarily based on cultivated or taxonomically classified species, neglecting microbial dark matter (MDM), which comprises lineages lacking reference genomes and is prevalent in wastewater communities. Herein, 3569 high- and medium-quality metagenome-assembled genomes were obtained from 69 full-scale wastewater treatment plants. A total of 1289 MDM lineages were identified to possess quorum sensing (QS) capabilities, designated as MDM-QSB. Among them, 127 novel genera were identified. These organisms possess larger genomes enriched in genes for energy metabolism and environmental information processing, allowing a broader ecological niche compared to non-QS MDM (

Indexed as

activated sludgecomplementarity networkco-occurrence networkcross-feedinggenome-scale metabolic modelingkeystonemachine learningmetagenomemetagenome-assembled genomessignaling molecule

Identifiers

PMID42841094
PMCPMC13641062

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.