ArticleInternational journal of women's health2026
Genetically Predicted IgG N-Glycosylation Traits and Risk of Pre-Eclampsia or Eclampsia: A Two-Sample and Multivariable Mendelian Randomization Study.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Maternal immunoglobulin G (IgG) has been implicated in placental and vascular dysfunction across pre-eclampsia and eclampsia. While clinical evidence supports the relevance of IgG-mediated immune regulation, whether specific IgG N-glycosylation traits-which critically regulate IgG concentration and effector function-are associated with the combined outcome of pre-eclampsia or eclampsia remains unclear. Methods: A two-sample Mendelian randomization (MR) study evaluated the causal relevance of 77 IgG N-glycosylation traits for the combined outcome of pre-eclampsia or eclampsia. Primary analysis utilized the inverse-variance weighted method, supported by robust outlier and sensitivity diagnostics. Multivariable MR (MVMR) was subsequently applied to adjust for body mass index, gestational diabetes, C-reactive protein, interleukin-6, and tumor necrosis factor-α. Results: Univariable MR identified nine IgG N-glycosylation traits nominally associated with pre-eclampsia or eclampsia: five risk-increasing (IGP6, IGP11, IGP22, IGP46, IGP51) and four risk-decreasing (IGP31, IGP48, IGP50, IGP58). Sensitivity analyses confirmed no residual heterogeneity or directional pleiotropy. In MVMR, IGP46, IGP48, and IGP58 retained nominal associations after adjustment for BMI, GDM, CRP, IL-6, and TNF-α, suggesting more stable covariate-adjusted associations among the suggestive UVMR signals. IGP46 was positively associated with pre-eclampsia or eclampsia, whereas IGP48 and IGP58 showed consistent inverse associations. Structural annotation indicated that these prioritized traits were mainly related to fucosylation and monogalactosylation of IgG glycans. Conclusion: This study provides suggestive genetic evidence that specific IgG N-glycosylation traits, particularly those related to core fucosylation and monogalactosylation, may be involved in the biological architecture of pre-eclampsia or eclampsia. The findings are hypothesis-generating and require validation in pregnancy-specific glycomic cohorts and functional studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.