ArticleFrontiers in molecular biosciences2026
Integrated microarray-based and single-cell transcriptomic analyses reveal cell adhesion-related fibrotic remodeling signatures in heart failure.
Article in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Heart failure (HF) is characterized by impaired cardiac pumping function and progressive remodeling. Cell adhesion is essential for tissue integrity and the regulation of inflammation and fibrosis. This study aimed to identify key cell adhesion-related genes (CARGs) and explore their roles in HF. Methods: HF-related transcriptomic datasets (GSE1621, GSE5500, GSE36074, GSE18224, GSE308859, and GSE116250) were obtained from GEO. Differentially expressed genes were intersected with cell adhesion-related genes from MSigDB to identify CARGs. Functional enrichment and protein-protein interaction analyses were performed. A CARG-based CelladhesionScore was constructed to evaluate its discriminatory value and associated pathways. Key CARGs were identified using CytoHubba. Single-cell transcriptomic analysis was conducted to assess fibroblast states and gene dynamics. GSE36074 and a transverse aortic constriction (TAC) mouse model were used for validation by qPCR, Western blotting, and immunohistochemistry. Results: Forty-five differentially expressed CARGs were identified and were mainly enriched in cell adhesion, extracellular region, and ECM-receptor interaction pathways. The CelladhesionScore distinguished HF samples from controls, while the high-CelladhesionScore group showed enrichment of fibrosis-related pathways. Conclusion:
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