ReviewFrontiers in immunology2026
From IL-6 production to IL-6R buffering: a unified IL-6-IL-6R framework for immune homeostasis during viral infection.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Interleukin-6 (IL-6) is a pleiotropic cytokine that coordinates innate and adaptive immunity and maintains tissue homeostasis during infection and inflammation. Although transient IL-6 production is essential for host defense, dysregulated or sustained IL-6 activity contributes to immunopathology across infectious and inflammatory diseases. Dengue virus (DENV) infection provides an important context in which this balance may become disrupted. Elevated circulating IL-6 levels are associated with endothelial dysfunction, vascular leakage, coagulopathy, and severe dengue; however, the mechanisms regulating IL-6 bioavailability, signaling duration, and resolution remain incompletely understood. Genetic variation within
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