ReviewFrontiers in public health2026
Dental composite-resin materials and oral-systemic health: clinical toxicology insights.
Review in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Resin-based dental composites are the most widely placed direct restorative materials globally. Yet, their organic matrix and complex filler system render them a potential source of biologically active compounds. Residual monomers, including Bisphenol A-glycidyl dimethacrylate (Bis-GMA), triethylene glycol dimethacrylate (TEGDMA), 2-hydroxyethyl methacrylate (HEMA), and urethane dimethacrylate (UDMA), are released into the oral environment through incomplete polymerization, material degradation, and wear, and may subsequently reach systemic circulation. Composite matrix breakdown additionally generates micro- and nanoplastic particles (MNPs), representing a distinct emerging exposure pathway. This review synthesizes clinical and translational evidence on the oral-systemic toxicological implications of resin-based composite materials, with emphasis on biomonitoring data, mechanistic pathways, and relevant risk signals. Methods: A structured search was conducted across PubMed/MEDLINE, Embase, Scopus, and Web of Science for studies published between January 1990 and September 2025. Eligible studies reported biomonitoring outcomes (saliva, blood, urine, breast milk, cord blood, or placenta), toxicokinetic profiles, or systemic and generalized hypersensitivity reactions attributable to resin-based restorative materials. Studies on dental amalgam and non-dental polymer exposures were excluded. Data were synthesized narratively in accordance with SANRA principles. Results: Released monomers exert concentration-dependent cytotoxic, genotoxic, and immunomodulatory effects, primarily through glutathione depletion, reactive oxygen species generation, and apoptosis induction. Local adverse effects, including gingival inflammation, pulp cytotoxicity, and allergic contact stomatitis, are well-documented Conclusion: Resin composites pose a measurable, if generally low-level, toxicological risk through monomer elution and, increasingly, MNP release. Adequate operative technique substantially reduces patient exposure. Vulnerable populations, including children, pregnant women, and dental personnel, warrant particular attention. Standardized biomonitoring protocols, updated regulatory thresholds, and dedicated
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