Lipid matrix composition-tuned nanoparticles for enhanced topical retinol delivery and anti-photoaging efficacy.

Hae Kyung Shin, Eun Yong Lee, Seunghyeon Lee, Chaelin Min, Minyoung Yi, Sung Yeon Cho, Sang Hyeon Bok, Young Hoon Roh

Abstract read

In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Hae Kyung ShinDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea.

Eun Yong LeeGraduate Program in Bioindustrial Engineering, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea.

Seunghyeon LeeDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea.

Chaelin MinDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea.

Minyoung YiDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea.

Sung Yeon ChoGraduate Program in Bioindustrial Engineering, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea.

Sang Hyeon BokGenewel, 6F, Star Tower 37, Sagimakgol-ro 2beon-gil, Jungwon-gu, Seongnam-si, Gyeonggi-do 13211, South Korea.

Young Hoon RohDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinol (Ret), a hydrophobic vitamin A derivative, is widely used for skin rejuvenation, inhibiting the degradation of major extracellular matrix components such as collagen. Ret has been incorporated into lipid nanoparticles, such as liposomes, to improve stability. However, the long-term stability of these formulations under temperature variations as well as systematic optimization remain unknown. To overcome these limitations, we developed a retinol-loaded nanostructured lipid carrier (Ret-NLC) by optimizing the solid-to-liquid ratio (SL ratio) to enhance long-term stability, cellular delivery efficacy, and skin permeation. The formulation was optimized at an SL ratio of 6:4, achieving a particle size of approximately 200 nm and acceptable size distribution (polydispersity index, PDI ≈ 0.3). Ret-NLC stored at 25 and 4 °C maintained favorable dispersion characteristics during 12 weeks of storage, and

Indexed as

Anti-aging efficacyAntioxidant activityLipid nanoparticleNanostructured lipid carrierRetinoidsTopical delivery

Identifiers

PMID42840803

DOI10.1016/j.ijpx.2026.100668

PMCPMC13639748

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.