Evidence map›Paper›PMID 42840758›Full record

ArticleFrontiers in bioengineering and biotechnology2026

ROS-responsive biomaterial delivery of the TCM-derived small molecule coptisine protects stem cells and attenuates intervertebral disc degeneration.

Shouyun Xiao, Ninghang Ruan, Bijun Wang, Beiduo Shen, Ziqi Zhu, Feng Wang, Yufeng Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shouyun Xiao *Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Ninghang Ruan *Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Bijun WangDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Beiduo ShenDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Ziqi ZhuDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Feng WangDepartment of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yufeng HuangDepartment of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress compromise nucleus pulposus-derived mesenchymal stem cells (NPMSCs) and restrict endogenous repair in intervertebral disc degeneration (IDD). Here, human nucleus pulposus (NP) tissues showed that secreted phosphoprotein 1 (SPP1) expression increased with degeneration severity. Screening of 2,987 traditional Chinese medicine (TCM)-derived compounds, followed by cellular validation, identified coptisine as a candidate that reduced SPP1 expression while increasing NP-associated extracellular matrix components in NPMSCs. However, effective intradiscal delivery requires sustained local exposure within the adverse degenerative microenvironment. We therefore embedded coptisine-loaded poly (lactic-co-glycolic acid) microspheres in phenylboronic acid-modified gelatin methacryloyl to form an ROS-responsive depot (Cop@PLGA-GelMA-PBA). The composite showed sustained, oxidant-accelerated release and good cytocompatibility. Under H

Indexed as

coptisineintervertebral disc degenerationnucleus pulposus-derived mesenchymal stem cellsoxidative stressROS-responsive biomaterial

Identifiers

PMID42840758
PMCPMC13640997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.