ArticleCancer management and research2026
A Retrospective Cohort Analysis of Risk Factors for Lymph Node Metastasis in Multiple Primary Lung Cancer with 215 Cases.
Article in Cancer management and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the pattern of lymph node metastasis (LNM) in multiple primary lung cancers (MPLC) and related influencing factors. Methods: We retrospectively analyzed the lymph node status of 215 patients with MPLC diagnosed by pathological and imaging examinations at Guangdong Jiangmen Central Hospital between January 2015 and December 2021, evaluating the relationship between age, smoking history, tumor markers, primary lesion diameter (PLD), pathological type, lesion location and LNM. Results: There were no statistically significant differences in age, smoking history, Cyfra 21-1, tumor location, or the number of lesions between groups regarding LNM. Binary logistic regression analysis demonstrated that CEA (OR=0.129, 95% CI=0.039-0.426), PLD (OR=0.377, 95% CI=0.207-0.689), and pathological type (OR=1.303, 95% CI=1.019-1.665) were independent risk factors. ROC analysis demonstrated that CEA and PLD could serve as potential predictive indicators for LNM, but a comprehensive model integrating multiple risk factors provided higher clinical predictive value. The LNM rate was significantly higher in patients with CEA > 5ng/mL than those with CEA ≤5ng/mL ( Conclusion: LNM in MPLC is associated with CEA, PLD and pathological type. Systematic lymph node dissection may be considered appropriate when PLD >20mm, CEA >5ng/mL, or when the tumor is SPA or MPA, whereas systematic lymph node sampling may be considered for ACI and other pathological types. These findings provide a preliminary framework that requires prospective validation.
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