ReviewFrontiers in immunology2026
hnRNPs in immunity: from nucleic acid sensing to lymphocyte fate determination.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a family of RNA-binding proteins long recognized for their roles in pre-mRNA processing. However, accumulating evidence has established hnRNPs as central and versatile regulators of immunity. In innate immunity, some hnRNP family members recognize nucleic acids and metabolites to either promote or constrain inflammatory gene expression in a context-dependent manner. In adaptive immunity, they play essential roles in B cell activation and germinal center (GC) responses, as well as T cell activation, survival, and differentiation, primarily through the precise regulation of alternative splicing (AS). Here, we review the functions of hnRNPs (with a focus on A1, A2B1, I, K, L, M, and U) across innate and adaptive immunity, and discuss critical unresolved questions, including the often-overlooked axis of species-specific regulation.
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