ReviewFrontiers in oncology2026
Spatial PK-PD mismatch in tumor-targeting antibodies and ADCs: from lesion access to pharmacologic execution.
Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic pharmacokinetics and target expression do not show whether tumor cells have received enough antibody to produce the intended effect. Tumor-targeting antibodies must reach individual lesions, cross tumor tissue, bind accessible targets, and, for some platforms, align with intracellular or neighboring-cell processes required for action. This critical narrative review organizes evidence by where exposure and effect become discordant. We define four spatial PK-PD mismatches (1): systemic exposure without adequate lesion access (2); lesion uptake without adequate microscopic distribution; (3) target expression without sufficient
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