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Survival and Recurrence Patterns After Total Laryngectomy in Young Laryngeal Squamous Cell Carcinoma Patients.
Article in OTO open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
Funding
Abstract
Objective: The prognostic role of age in laryngeal squamous cell carcinoma (LSCC) remains unclear, particularly regarding recurrence after total laryngectomy (TL). This study evaluated the impact of age on LSCC outcomes following TL. Study Design: Retrospective single-institution cohort study. Setting: Academic tertiary medical center. Methods: We reviewed LSCC patients who underwent TL between 1999 and 2024 grouped by age at surgery: <45 versus ≥45 years. Overall survival (OS) and disease-free survival (DFS) were assessed using Kaplan-Meier and log-rank tests. Site-specific recurrence was analyzed using cumulative incidence functions with Gray's test. Multivariable competing risk regressions with the Fine-Gray model evaluated the association of age with recurrence. Results: Among 646 TL patients, 17 were <45 years. Five-year OS was 82.0% for <45 versus 54.3% for ≥45 ( Conclusions: Younger LSCC TL patients demonstrated improved OS and DFS despite comparable recurrence risk. Age was not independently associated with recurrence, suggesting that improved survival in younger patients does not reflect differences in oncologic control. These findings highlight the importance of distinguishing survival from recurrence outcomes and underscore the need for larger studies evaluating survival differences in younger patients.
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