Evidence map›Paper›PMID 42840606›Full record

Trial reportJMA journal2026

Design Paper: The Short- and Long-term Effects of Inspiratory Muscle Training in Patients with Idiopathic Pulmonary Fibrosis-A Multicenter Randomized Controlled Trial (the Breathe IPF Trial).

Akihito Okada, Hiroaki Nakagawa, Tomohiro Handa, Yuta Kono, Naozumi Hashimoto, Yohei Oshima, Kohei Ikezoe, Yoshinari Nakatsuka, Naoya Tanabe, Susumu Sato and 11 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JMA journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Akihito OkadaDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Hiroaki NakagawaDivision of Respiratory Medicine, Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan.
Tomohiro HandaDepartment of Advanced Medicine for Respiratory Failure, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yuta KonoDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Naozumi HashimotoDepartment of Respiratory Medicine, Fujita Health University, Toyoake, Japan.
Yohei OshimaRehabilitation Unit, Kyoto University Hospital, Kyoto, Japan.
Kohei IkezoeDepartment of Advanced Medicine for Respiratory Failure, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yoshinari NakatsukaDepartment of Advanced Medicine for Respiratory Failure, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Naoya TanabeDepartment of Advanced Medicine for Respiratory Failure, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Susumu SatoDepartment of Advanced Medicine for Respiratory Failure, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kenichi KobayashiDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Ryota KikuchiDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Mayuko IshiwariDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Mariko KogamiDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Shinji AbeDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Yoshitsugu InoueDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Kohei FujitaDepartment of Respiratory Medicine, Nagoya City University East Medical Center, Nagoya, Japan.
Akiko NakanoDepartment of Respiratory Medicine and Allergy, Nagoya City University Midori Municipal Hospital, Nagoya, Japan.
Eiji NakataniDepartment of Biostatistics and Health Data Science, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
Kenichi YoshimuraDepartment of Biostatistics and Health Data Science, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
Hirotsugu OhkuboDepartment of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Pulmonary rehabilitation is beneficial for patients with idiopathic pulmonary fibrosis (IPF) but is often limited by poor adherence. Inspiratory muscle training (IMT) may represent a more feasible, home-based alternative. This trial aims to evaluate the short- (8-week) and long-term (56-week) effects of IMT using the POWERbreathe Medic Plus in patients with IPF. Methods: This multicenter, open-label, parallel-group, randomized controlled trial will assess the efficacy and safety of device-based IMT. Eligible participants (aged 40-85 years) with stable IPF and modified Medical Research Council dyspnea grades 1-3 will be randomly assigned (1:1) to an IMT group or a control group receiving usual care. The primary endpoint is the change in the St. George's Respiratory Questionnaire activity domain score from baseline to week 8. Secondary endpoints include pulmonary function, exercise capacity, dyspnea, and quality of life over 56 weeks. Results: This trial will clarify the short- and long-term effects of IMT, as well as its safety, in patients with IPF. Conclusions: This study is the first to evaluate both the short- and long-term effects of IMT on quality of life in IPF. Protocol Registration: The Japan Registry of Clinical Trials (jRCT1042250003).

Indexed as

idiopathic pulmonary fibrosisinspiratory muscle trainingpulmonary rehabilitationquality of life

Identifiers

PMID42840606
PMCPMC13639472

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.