ArticleFrontiers in veterinary science2026
Prognostic indicators associated with 2-week survival and postoperative antimicrobial use following ovariohysterectomy for canine pyometra from 2012 to 2021: a multicenter retrospective cohort of 470 cases.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to retrospectively evaluate factors associated with 2-week survival following ovariohysterectomy for pyometra in dogs. Animals: This study included 470 intact bitches that underwent ovariohysterectomy for pyometra. Methods: In this multi-institutional retrospective cohort study, medical records were reviewed for clinical data, including signalment, duration of clinical signs, blood count findings, presence of septic peritonitis, culture and susceptibility results, antibiotics prescribed and duration, and survival at 2 weeks postoperatively (from the medical record or via owner contact). A univariable analysis was performed due to the low mortality rate to evaluate the association between variables and 2-week survival. Results: Four hundred and fifty-two dogs survived to discharge, of which 10 dogs (2.2%) did not survive the 2-week follow-up. Eighteen dogs (3.8%) did not survive to discharge (DNSD). Post-discharge 2-week survival was 97.8% (442/452) and was associated with younger age and the absence of pre-operative azotemia, hyperkalemia, and hypoglycemia ( Clinical significance: Younger dogs that were presented for pyometra without azotemia, hyperkalemia, and/or hypoglycemia had improved 2-week postoperative survival. An association between postoperative discharge antibiotic use and 2-week survival was not identified in this study. Further studies with greater statistical power are needed to evaluate the potential effect of postoperative antibiotic use on survival.
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