Evidence map›Paper›PMID 42840554›Full record

ReviewJMA journal2026

Antigen-Presenting Cancer-Associated Fibroblasts Modulate Tumor Microimmunity.

Yasuhiro Fukui, Hiroaki Kasashima, Nobuhiro Naito, Zizhou Wang, Iguru Omori, Yuki Seki, Masatsune Shibutani, Yu Muta, Yuki Nakanishi, Masakazu Yashiro and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JMA journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yasuhiro FukuiDepartment of Gastroenterological Surgery, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan.
Hiroaki KasashimaDepartment of Gastroenterological Surgery, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan.
Nobuhiro NaitoDepartment of Gastroenterological Surgery, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan.
Zizhou WangDepartment of Gastroenterological Surgery, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan.
Iguru OmoriDepartment of Gastroenterological Surgery, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan.
Yuki SekiDepartment of Gastroenterological Surgery, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan.
Masatsune ShibutaniDepartment of Gastroenterological Surgery, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan.
Yu MutaDepartment of Gastroenterology and Hepatology, Kyoto University, Graduate School of Medicine, Kyoto, Japan.
Yuki NakanishiDepartment of Gastroenterology and Hepatology, Kyoto University, Graduate School of Medicine, Kyoto, Japan.
Masakazu YashiroDepartment of Molecular Oncology and Therapeutics, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan.
Naoko OhtaniDepartment of Pathophysiology, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan.
Kiyoshi MaedaDepartment of Gastroenterological Surgery, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer-associated fibroblasts (CAFs) are key regulators of tumor progression, immune modulation, and therapeutic resistance within the tumor microenvironment. Advances in single-cell and spatial profiling have revealed substantial heterogeneity among CAF populations, challenging the traditional view of CAFs as a uniformly tumor-promoting stromal population. Among the identified fibroblast states, antigen-presenting CAFs (apCAFs) represent a distinct subset characterized by major histocompatibility complex class II expression and the ability to directly interact with cluster of differentiation (CD) 4

Indexed as

antigen presentationantigen-presenting cancer-associated fibroblastfibrocytemesothelial celltumor microenvironment

Identifiers

PMID42840554
PMCPMC13639424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.