Harm reduction vending machines as safer supply-supporting infrastructure.

The increasingly unpredictable unregulated drug supply has intensified overdose morbidity and mortality and prompted growing interest in safer regulated supply as an upstream harm reduction strategy. Yet, safer supply programs cannot function effectively as stand-alone interventions. Their reach, acceptability, and equity will depend on surrounding infrastructure that supports people before enrollment, during transitions in substance use or dosing, and alongside ongoing use of unregulated substances. Harm reduction vending machines (HRVMs) are one low-barrier infrastructure model that can support safer supply ecosystems without conflating automated harm reduction supply distribution with regulated drug dispensing. Drawing on implementation experience from a Veteran-serving HRVM program across hospital, outpatient clinic, and permanent supportive housing settings, this article describes how HRVMs can expand access to drug checking supplies, naloxone, safer use materials, wound care and hygiene supplies, HIV and sexually transmitted infection prevention resources, and voluntary care linkage pathways while potentially reducing the need for face-to-face disclosure. Six HRVM infrastructure functions relevant to safer supply implementation are proposed: drug checking access, overdose prevention, safer use and wound care, health and wellness supplies, syndemic prevention, and noncoercive linkage to care. Design and evaluation considerations include privacy protection, product adaptability, co-design with people who use drugs, operational reliability, and the need to distinguish implementation metrics from clinical outcomes. Positioning HRVMs as safer supply-supporting infrastructure may help health systems, community programs, housing providers, and policymakers build more accessible, adaptive, and person-centered harm reduction ecosystems.