ArticleiScience2026
The misplaced mouse Pax6 interneuron subclass: A cross-species transcriptomic reassignment.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Subclass cell types are strongly conserved across mammalian brains, making the systemic absence of a caudal ganglionic eminence (CGE) Pax6 interneuron subclass in mouse transcriptional atlases unexpected. Through cross-species transcriptomic analysis, we identify a Pax6 subclass homolog in mouse and uncover primate-specific divergence in the Sncg subclass. Analyses of electrophysiological and spatial datasets reveal limited subclass-specific structure in either modality, emphasizing the superior resolving power of transcriptomics for subclass distinctions. Our results highlight the pitfalls of relying on small sets of marker genes in cell-type annotation and provide evolution-aware annotations and marker sets to support robust cross-mammal interneuron comparisons.
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