Evidence map›Paper›PMID 42840460›Full record

ReviewFrontiers in genetics2026

Tissue-specific aging-a new paradigm based on transcriptional insights from select model systems and humans.

Stewart Frankel, Blanka Rogina

Abstract readReview
In one paragraph

Review in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stewart FrankelDepartment of Biology, University of Hartford, West Hartford, CT, United States.
Blanka RoginaDepartment of Genetics and Genome Sciences, School of Medicine, University of Connecticut Health Center, Farmington, CT, United States.

Funding

Research Education ComponentP30AG067988 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Richard H Fortinsky, GEORGE A KUCHEL · 2021 to 2026
$9.5M
Non-Autonomous control of aging in DrosophilaR01AG059586 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ROGINA, BLANKA · 2018 to 2022
$2.5M
Calorie Restriction and Hallmarks of Aging in DrosophilaR56AG082788 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ROGINA, BLANKA · 2023 to 2023
$415k
NIA NIH HHS P30 AG067988NIA NIH HHS R01 AG059586NIA NIH HHS R56 AG082788
6 · The paper itself

Abstract

Aging is a complex process affected by genes and modified by environment. The forefront of aging research has moved from the level of organisms to the level of tissues and single cells, analyzed using bulk tissue and single-cell transcriptomes. Transcriptomics provides high resolution, comprehensive information per sample, and scalability to large numbers of samples. Datasets obtained from multiple tissues at multiple time points indicate that each tissue ages differently. The transcriptomic approach promises to greatly widen the identification of the candidate mechanisms and genes driving aging-related changes, which could then be tested in model organisms. Our focus here will be work in

Indexed as

agingcell atlascell typeevolutiongene expressiontissue-agingtissue-specifictranscriptome

Identifiers

PMID42840460
PMCPMC13639267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.