ArticleiScience2026
B cells in the retinal pigment epithelium change with aging and IgM availability.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
Abstract
Maintenance of the retina, the CNS tissue responsible for vision, is critical during aging. Historically considered immune privileged, the retina was thought to lack traditional immune components with resident glial cells maintaining tissue integrity. Emerging evidence suggests that immune suppression, rather than immune absence, governs retinal tolerance. Here, we identify B lymphocytes isolated from the retinal pigment epithelium (RPE), a CNS barrier niche, and show that their activation state and antibody repertoire are associated with secreted immunoglobulin M (IgM) availability and aging. In the absence of secreted IgM, B cells isolated from the RPE display a more activated phenotype and an altered B cell receptor repertoire, with age further modifying VH usage and CDR-H3 properties and expansion. Functionally, RPE B cells secrete antibodies following stimulation. These findings provide a foundation for understanding humoral regulation in CNS barrier tissues and mechanisms linking immune function to retinal aging and health.
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