Evidence map›Paper›PMID 42840318›Full record

ArticleHuman mutation2026

A Regulator SNP Affecting the Transcription Factor

Long Miao, Jiaxuan Zhou, Man Qu, Yu Xue, Xiuli Zhao, Xiaoqin Li, Yang Wang, Shuang Qiu

Abstract read
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Long MiaoSchool of Nursing and School of Public Health Yangzhou University Yangzhou China yzu.edu.cn.ORCID https://orcid.org/0000-0001-6949-5855
Jiaxuan ZhouSchool of Nursing and School of Public Health Yangzhou University Yangzhou China yzu.edu.cn.ORCID https://orcid.org/0009-0003-3695-448X
Man QuSchool of Nursing and School of Public Health Yangzhou University Yangzhou China yzu.edu.cn.ORCID https://orcid.org/0000-0003-0144-6971
Yu XueDepartment of Radiology and Functional Examination Nanjing Prevention and Treatment Center for Occupational Diseases Nanjing China.ORCID https://orcid.org/0009-0002-0297-5509
Xiuli ZhaoSchool of Nursing and School of Public Health Yangzhou University Yangzhou China yzu.edu.cn.ORCID https://orcid.org/0000-0001-6519-7244
Xiaoqin LiDepartment of Occupational Health Yangzhou Center for Disease Control and Prevention Yangzhou China.ORCID https://orcid.org/0009-0007-0650-7995
Yang WangYangzhou Hospital of Traditional Chinese Medicine Affiliated to the School of Clinical Chinese Medicine Yangzhou University Yangzhou China yzu.edu.cn.ORCID https://orcid.org/0009-0000-0531-3098
Shuang QiuYangzhou Hospital of Traditional Chinese Medicine Affiliated to the School of Clinical Chinese Medicine Yangzhou University Yangzhou China yzu.edu.cn.ORCID https://orcid.org/0009-0003-0401-4725

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Noise-induced hearing loss (NIHL) is a key occupational hazard, and its specific pathogenic mechanism is not fully elucidated. Here, we performed this study to explore the potential role of single nucleotide polymorphisms (SNPs) located in the Methods: A case-control study including 688 NIHL patients and 667 normal subjects was conducted. Genotype analysis was tested by multiplex polymerase chain reaction (PCR) with next generation sequencing. Luciferase assays were conducted to explore the effect of Results: Subjects with Conclusion: All findings demonstrate that rs7536272 influences NIHL susceptibility by regulating

Indexed as

Genetic Predisposition to DiseaseHearing Loss, Noise-InducedPhosphatidylinositol 3-KinasesPolymorphism, Single NucleotideSp1 Transcription FactorApoptosisAutophagyBinding SitesCase-Control StudiesCell LineFemaleGene Expression RegulationGenotypeHumansMaleMiddle AgedPhosphatidylinositol 3-KinasesPIK3R3 protein, humanProto-Oncogene Proteins c-aktSP1 protein, humanSp1 Transcription Factornoise-induced hearing lossPI3K/AKT pathwayPIK3R3single nucleotide polymorphismsSP1

Identifiers

PMID42840318
PMCPMC13639393

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.