Evidence map›Paper›PMID 42840205›Full record

ArticleFrontiers in chemistry2026

Evaluation of the phytochemical profile, biological activities, and acute toxicity of

Fatima Zahra Ayyad, Mouad Lahyaoui, Hajar Lahyaoui, Morad Kaddouri, Mohamed El Yaqoubi, Mouhcine Hayani, Amina Bari, Ahde El Imache, Joe Miantezila Basilua, Abdelaaty A Shahat and 2 more

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Article in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fatima Zahra AyyadResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.
Mouad LahyaouiLaboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University, USMBA, Fez, Morocco.
Hajar LahyaouiLaboratory of Innovative Technologies, Process Engineering Department, Higher School of Technology Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Morad KaddouriLaboratory of the Engineering and Applied Technologies, Higher School of Technology, Sultan Moulay Slimane University, Beni Mellal, Morocco.
Mohamed El YaqoubiLaboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University, USMBA, Fez, Morocco.
Mouhcine HayaniResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.
Amina BariLaboratory of Biotechnology, Environment, Agri-food, and Health, Faculty of Sciences, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Ahde El ImacheLaboratory of Innovative Technologies, Process Engineering Department, Higher School of Technology Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Joe Miantezila BasiluaDepartment of Biostatistics and Mathematics, Faculty of Pharmacy, Paris Cité University, Paris, France.
Abdelaaty A ShahatDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mohammed S AlharbiCenter for Research on Medicinal, Aromatic, and Poisonous Plants, DSR, King Saud University, Riyadh, Saudi Arabia.
Touriya ZairResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Using both experimental and Methods: Cistus ladanifer aerial parts were collected in the Khenifra region, Morocco. Hydroethanolic (Soxhlet) and aqueous (decoction) extracts were prepared. Physicochemical parameters, mineral content (ICP-AES), phytochemical screening, total polyphenols, flavonoids, and condensed tannins were determined. HPLC/UV-ESI-MS was used for chemical profiling. Antioxidant activity was assessed by TAC, DPPH, and FRAP assays; antimicrobial activity by MIC and MBC/MFC against bacterial and fungal strains; acute toxicity in mice at 2 g/kg; antihyperglycemic activity by oral glucose tolerance test in rats; and molecular docking against selected antioxidant, antimicrobial, and antihyperglycemic protein targets. Results: Physicochemical analysis of the plant material showed a moisture content of 12.68% ± 0.42%, pH of 4.16 ± 0.05, and ash content of 5.50% ± 0.31%. Mineral analysis revealed essential elements such as Zn, Mn, Fe, and Al. Phytochemical screening confirmed major secondary metabolites, including flavonoids, tannins, saponins, and alkaloids. The hydroethanolic extract exhibited the highest extraction yield (23.81% ± 0.63%), whereas the aqueous extract ( Discussion: Our findings highlight

Indexed as

antihyperglycemicantimicrobialantioxidantCistus ladaniferin silicotoxicity

Identifiers

PMID42840205
PMCPMC13638642

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