ArticleFrontiers in public health2026
Accelerometer-measured physical activity and risk of incident ulcerative colitis: a population-based prospective study.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Ulcerative colitis (UC) lacks established primary prevention strategies despite its economic burden. Physical activity (PA) is promising, yet studies using self-reported data show inconsistent results. We examined the association between accelerometer-measured physical activity and UC risk in a large prospective cohort. Methods: This cohort study analyzed data from 95,197 UK Biobank participants without baseline inflammatory bowel disease and with valid accelerometer data, with follow-up from 2013 to 2015 through 2023. Machine learning models estimated time spent in sedentary behavior, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA). MVPA patterns were categorized as active weekend warriors (≥231.5 min/week, ≥50% in 1-2 days), active regular (≥231.5 min/week, not meeting weekend warrior criteria), and inactive (<231.5 min/week). Cox proportional hazards regression assessed associations between PA and UC risk. Results: Over 8.86 years median follow-up, 247 incident UC cases were recorded. MVPA showed a dose-response relationship with UC risk (trend Conclusion: Accelerometer-measured MVPA is associated with reduced UC risk. Both weekend warrior and regular MVPA patterns conferred protection, suggesting that flexibility in exercise scheduling may be feasible.
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