Evidence map›Paper›PMID 42840108›Full record

ArticleFrontiers in microbiology2026

Advanced applications of cationic photosensitizer DHPC in photodynamic eradication of drug-resistant bacteria.

Hongshuang Qin, Lu Dong, Yinan Liu, Zitong Zhai, Xiaohui Jia, Delong Meng, Xueyi Sun, Yanxiang Guo, Li Feng, Tao Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongshuang QinDepartment of Biological and Food Engineering, Lyuliang University, Lvliang, Shanxi, China.
Lu DongDepartment of Biological and Food Engineering, Lyuliang University, Lvliang, Shanxi, China.
Yinan LiuDepartment of Biological and Food Engineering, Lyuliang University, Lvliang, Shanxi, China.
Zitong ZhaiDepartment of Biological and Food Engineering, Lyuliang University, Lvliang, Shanxi, China.
Xiaohui JiaSchool of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, China.
Delong MengSchool of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, China.
Xueyi SunDepartment of Chemistry and Chemical Engineering, Lyuliang University, Lvliang, Shanxi, China.
Yanxiang GuoDepartment of Biological and Food Engineering, Lyuliang University, Lvliang, Shanxi, China.
Li FengDepartment of Cardiology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Tao LiuDepartment of Chemistry and Chemical Engineering, Lyuliang University, Lvliang, Shanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) is increasingly viewed as a reliable and effective treatment for infections caused by antibiotic-resistant bacteria. However, the limited uptake of photosensitizers (PS) by bacteria remains a major challenge. Cationization enables PS to accumulate around bacterial cells, thereby promoting their intracellular delivery. In particular, cationic small-molecule PS are characterized by carrier-free bacterial enrichment, efficient biofilm penetration, high stability, straightforward synthesis, and moderate charges that minimize toxicity, making them a sustained focus in antimicrobial PS development. Herein, we investigate the potential of a cationic small-molecule PS, DHPC [(E)-8-(diethylamino)-2-(4-(diethylamino)-2-hydroxystyryl)-4-oxo-4H-pyrano[2,3-b]chromen-10-ium], for combating drug-resistant pathogens. Our results demonstrate that DHPC-mediated PDT (DHPC-PDT) effectively eradicates drug-resistant bacteria, including antibiotic-resistant

Indexed as

biofilmcationic photosensitizerdrug-resistant bacteriareactive oxygen specieswound healing

Identifiers

PMID42840108
PMCPMC13638522

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.