SynthesisFrontiers in nutrition2026
Effects of soy and isoflavone interventions on plasma lipid profiles in postmenopausal women: an umbrella review.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
14 authors.
Funding
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Abstract
Background: Although numerous meta-analyses have investigated the effects of soy and isoflavones on lipid profiles in postmenopausal women, a comprehensive evaluation of this evidence remains lacking. This umbrella review synthesized existing meta-analyses of randomized controlled trials to assess the certainty of the evidence. Methods: We searched PubMed, Web of Science, Embase, and the Cochrane Database for studies published through April 22, 2026. Methodological quality was evaluated using AMSTAR-2, and evidence certainty was assessed using the GRADE approach. Results: Seven meta-analyses comprising 21 associations were included. According to AMSTAR-2, two meta-analyses (29%) demonstrated moderate or high quality. Eighteen associations were supported by evidence of moderate or high certainty according to GRADE. Soy protein containing isoflavones and soy isoflavone extracts significantly reduced total cholesterol (MD = -0.12 mmol/L, 95% CI: -0.21 to -0.03). Soy isoflavones reduced low-density lipoprotein cholesterol (SMD = -0.11, 95% CI: -0.21 to -0.01). Furthermore, unfermented soy products significantly increased high-density lipoprotein cholesterol (MD = 0.06 mmol/L, 95% CI: 0.02 to 0.10). Conclusion: Specific soy-based interventions, rather than general soy consumption, were associated with beneficial changes in lipid profiles among postmenopausal women. Systematic review registration: CRD420251243075.
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