Evidence map›Paper›PMID 42840093›Full record

ArticleFrontiers in microbiology2026

YtnP lactonase from

Bin Liu, Caihua Li, Yizhen Zhu, Mengxia Zhu, Jilai Yin, Lei Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bin Liu *Key Laboratory of Emergency and Trauma of Ministry of Education, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Caihua Li *Key Laboratory of Emergency and Trauma of Ministry of Education, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Yizhen Zhu *Key Laboratory of Emergency and Trauma of Ministry of Education, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Mengxia ZhuKey Laboratory of Emergency and Trauma of Ministry of Education, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Jilai YinKey Laboratory of Emergency and Trauma of Ministry of Education, Department of Microbiology Laboratory, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Lei LiuKey Laboratory of Emergency and Trauma of Ministry of Education, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Backgroud: Carbapenem-resistant Methods: In this study, we isolated a N-acyl homoserine lactonase YtnP from mangrove rhizosphere-derived Results: YtnP is a 280-amino-acid metalloenzyme of approximately 30 kDa containing a conserved HXHXDH motif, exhibiting optimal activity at 37°C -45°C and pH 7.0-7.5. Distinct from classical lactonases, YtnP maintained high catalytic activity without exogenous Zn Conclusion: Collectively, mangrove-derived YtnP acts as a potent quorum-quenching enzyme that suppresses CRAB biofilm formation and virulence in a non-bactericidal manner. This work highlights the potential of YtnP as a promising anti-virulence adjuvant candidate for the development of alternative therapeutic strategies against intractable CRAB infections.

Indexed as

anti-virulence therapybiofilm disruptioncarbapenem-resistant Acinetobacter baumanniiquorum quenchingYtnP

Identifiers

PMID42840093
PMCPMC13638630

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.