ArticleFrontiers in rehabilitation sciences2026
Effectiveness of tailored individual follow-up vs. standard one-day group course on health-related quality of life in patients with post COVID-19 condition: a randomized controlled trial.
Article in Frontiers in rehabilitation sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Background: Post COVID-19 condition (PCC), is characterized by a wide range of symptoms, including fatigue and cognitive problems. Symptoms may lead to disability in everyday life and reduced health-related quality of life (HRQoL). Evidence for effective rehabilitation strategies for this patient group remains limited. Objective: To examine the effectiveness of tailored individual follow-up compared with a standard one-day group course, both based on cognitive behavioral approach, in patients with PCC 6 months after the intervention. Methods: A single-center, parallel-group, superiority randomized controlled trial (1:1) was conducted among outpatients aged 18-65 years with PCC. Patients were randomized to either a rehabilitation program with individual follow-up over 6-8 weeks or a standard one-day multidisciplinary self-management group course. Both groups were introduced to graded activity based on principles from cognitive behavioral therapy (CBT) and were offered the app "My COVID rehabilitation". The primary outcome was the between-group difference in patient reported HRQoL (EQ-5D-5L-index score) at 6 months. Secondary self-reported outcomes included fatigue measured with the Chalder Fatigue Scale, EQ-VAS, and symptom registration. Neuropsychological function was assessed with objective neuropsychological tests. Results: 60 participants were randomized, the mean age was 46 years (22-66 years), and 43 (72%) were female. Outcome assessments were completed for the primary outcome for 29 participants in each arm. No significant between-group difference was found in the primary outcome (score difference EQ-5D-5L-index =0.07; 95% CI [-0.18,.04]; Conclusion: Tailored individual follow-up was not more effective than a standard one-day group course in improving HRQoL in PCC, both based on principles of CBT. However, significant improvements in both groups were observed in several secondary outcomes, including some objective neuropsychological tests. Larger studies are needed to confirm these results.
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