Evidence map›Paper›PMID 42840060›Full record

ArticleFrontiers in pharmacology2026

Ulcerative colitis therapeutic effects and pharmacokinetics of flexible quercetin nanocrystals prepared with geniposide assistance.

Wei Lv, Haobo Liu, Haixian Feng, Huiqin Xue, Jiale Wen, Xinlei Fu, Xiaohong Zhang, Yongtai Xv, Huanyun Wang, Shibing Guo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei Lv *College of Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Haobo Liu *College of Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Haixian Feng *Pharmacy Department, Hohhot Mongolian Medicine of Traditional Chinese Medicine Hospital, Hohhot, China.
Huiqin XueNursing Department, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Jiale WenCollege of Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Xinlei FuCollege of Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Xiaohong ZhangCollege of Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Yongtai XvCollege of Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Huanyun WangCollege of Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Shibing GuoNursing Department, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Shikui WuCollege of Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to improve the oral bioavailability and therapeutic efficacy of quercetin (QUE) against ulcerative colitis (UC) by formulating flexible quercetin nanocrystals (QUE-NCs) with the assistance of geniposide (Gen). Methods: QUE-NCs were prepared via an antisolvent precipitation method leveraging the interaction between QUE and Gen. Therapeutic efficacy was evaluated in a dextran sulfate sodium (DSS)-induced UC mouse model using disease activity index (DAI), colon histopathology (H&E), and ELISA-based biochemical assays. Biosafety was assessed through serum biochemistry, organ indices, and histopathological examination. An HPLC method was developed and validated for quantifying QUE in rat plasma, followed by a pharmacokinetic study in Wistar rats. Results: QUE-NCs exhibited a flexible rod-like morphology and significantly alleviated UC symptoms, including weight loss, fecal occult blood, and colonic damage. Treatment with QUE-NCs reduced pro-inflammatory cytokines (TNF-α: 173.51 pg·mL Conclusion: Gen-assisted formulation of QUE-NCs improves both the oral absorption and anti-UC efficacy of QUE, offering a promising nanostrategy for flavonoid-based therapeutic development.

Indexed as

bioavailabilitygeniposidenanocrystalsquercetinulcerative colitis

Identifiers

PMID42840060
PMCPMC13638574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.