ArticleFrontiers in neurology2026
Association of a platelet function testing-guided intensified antiplatelet strategy with thromboembolic events after EP2 stent-assisted coil embolization in patients with unruptured intracranial aneurysms.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: To evaluate the association of Platelet Function Testing (PFT)-guided intensified antiplatelet strategy with the incidence of thromboembolic events and bleeding rates in patients with Unruptured Intracranial Aneurysms (UIA) undergoing stent-assisted coil embolization, compared with standard fixed-dose Dual Antiplatelet Therapy (DAPT). Methods: In this retrospective study, 368 patients from two centers between January 2019 and September 2024 were enrolled and categorized into a Monitored Group ( Results: In the original cohort, the monitored strategy was associated with a lower incidence of the primary 7-day composite thromboembolic outcome (3.20% vs. 8.05%; unadjusted HR = 0.388, 95%CI 0.153-0.985, Conclusion: A PFT-guided intensified antiplatelet strategy was associated with a lower incidence of early post-procedural thromboembolic events without a significant increase in major bleeding in UIA patients treated with EP2 stent-assisted coiling. These findings support the potential utility of this comprehensive strategy, although the independent contribution of each component requires further investigation in larger prospective studies.
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