The shifts of submucosal microbiota in treated patients with aggressive periodontitis.

Qiao Shi, Wenmin Zeng, Yu Cai, Qingxian Luan, Jing Zang, Xiaoqian Yu, Guojing Liu

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Article in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Qiao Shi *Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Department of Periodontology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.

Wenmin Zeng *Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Department of Periodontology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.

Yu CaiBeijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Department of Periodontology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.

Qingxian LuanBeijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Department of Periodontology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.

Jing ZangDepartment of Stomatology, Peking University Third Hospital, Beijing, China.

Xiaoqian YuBeijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Department of Periodontology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.

Guojing LiuBeijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Department of Periodontology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study aimed to investigate the evolution of the submucosal microbiota and compare the submucosal and subgingival microbiota in patients with aggressive periodontitis. Methods: Patients with aggressive periodontitis underwent initial periodontal and surgical therapy, followed by implant restoration. Samples were longitudinally collected from the teeth and implants before the initial therapy (V0), before implantation (V1), one month after abutment connection (V2), one month (V3) and one year (V4) after restoration. The 16S rRNA V3-V4 region of subgingival and submucosal samples was analyzed using the MiSeq platform. Results: A total of 108 subgingival pooled samples and 24 submucosal pooled samples from 6 patients were sequenced to generate 3,129 operational taxonomic units (OTUs) capturing 12 phyla, 27 classes, 49 orders, 92 families, 195 genera, and 554 species. A considerable microbial shift was observed from 1 month after abutment connection to 1 month after loading (V2 to V3); however, this shift slowed during the remaining study period. One year after loading, a similarity of 76.14% was observed between the microbiota of the implants and that of the teeth. Conclusions: The submucosal microbiota showed 76.14% similarity in bacterial composition with residual teeth but exhibited more dynamic evolutionary characteristics during the first year after restoration.

Indexed as

aggressive periodontitisdental implantlongitudinal studymicrobiotaresidual teeth

Identifiers

PMID42839959

DOI10.3389/froh.2026.1855289

PMCPMC13638358

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