Evidence map›Paper›PMID 42839750›Full record

ArticleEnvironmental and molecular mutagenesis2026

Trp53 Deficiency Increases the Frequency of Hprt Mutant T Lymphocytes Following High-LET Iron Particle Irradiation of Mice.

Vernon E Walker, Dale M Walker, Vasily N Dobrovolsky, Louise Lutze-Mann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental and molecular mutagenesis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vernon E WalkerNew York State Department of Health, Wadsworth Center, Albany, New York, USA.ORCID https://orcid.org/0000-0003-0299-7177
Dale M WalkerExperimental Pathology Laboratories, Sterling, Virginia, USA.
Vasily N DobrovolskyDivision of Genetic and Molecular Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, USA.
Louise Lutze-MannSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.

Funding

Pharmacological and dietary inhibition of a novel metabolic-epigenetic crosstalk in head and neck cancerR01DE033648 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI De-Chen Lin · 2024 to 2026
$1.5M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01 HD33648NASA NAG5-6177NIDCR NIH HHS R01 DE033648
6 · The paper itself

Abstract

Charged particles like iron-56 ions impose health risks in long-term manned space exploration. This study was designed to define the impact of Trp53 status upon the manifestation of mutations in the hypoxanthine-guanine phosphoribosyltransferase (Hprt) gene in splenic T-cells following exposure of Trp53 wild-type, hemizygous, and nullizygous lacZ transgenic mice to 1 Gy

Indexed as

Hypoxanthine PhosphoribosyltransferaseIronMutationT-LymphocytesTumor Suppressor Protein p53AnimalsFemaleMaleMiceMice, Inbred C57BLMice, TransgenicSpleenHypoxanthine PhosphoribosyltransferaseIronTrp53 protein, mouseTumor Suppressor Protein p53

Identifiers

PMID42839750
PMCPMC13643343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.