Evidence map›Paper›PMID 42839644›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Metabolic-Redox Remodeling of Inflammatory Synovium by Mannose-Modified Selenium Nanoparticles for Osteoarthritis Therapy.

Yu-Qing Zou, Chen-Hao Xu, Bo-Wei Li, Leung Chan, Yi-Di Xu, Han-Bo Su, Rui Peng, Fang-Ji Luo, Ya-Chen Peng, Zhen-Yan Li and 6 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yu-Qing Zou *Department of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0001-6313-1970
Chen-Hao Xu *Department of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.
Bo-Wei Li *Department of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.
Leung Chan *Department of Chemistry, Institute of Nanotechnology and Intelligence (inAI), College of Chemistry and Materials Science, Jinan University, Guangzhou, China.
Yi-Di XuDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.
Han-Bo SuDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.
Rui PengDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.
Fang-Ji LuoDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.ORCID https://orcid.org/0009-0007-1752-1661
Ya-Chen PengDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.
Zhen-Yan LiDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.
Vincent Kam Wai WongDr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicines, Macau University of Science and Technology, Macao, China.ORCID https://orcid.org/0000-0002-2951-8108
Xiao-Fei ZhengDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0001-7502-6131
Xing MaSauvage Laboratory for Smart Materials, School of Integrated Circuits, Harbin Institute of Technology (Shenzhen), Shenzhen, China.ORCID https://orcid.org/0000-0002-2248-4806
Zhen-Gang ZhaDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.
Tianfeng ChenDepartment of Chemistry, Institute of Nanotechnology and Intelligence (inAI), College of Chemistry and Materials Science, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0001-6953-1342
Huan-Tian ZhangDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0002-7391-436X

Funding

China Postdoctoral Science Foundation 2025M782023Guangdong Basic and Applied Basic Research Foundation 2023B1515020007Guangdong Basic and Applied Basic Research Foundation 2024A1515010822Guangdong Basic and Applied Basic Research Foundation 2025A1515012317K. C. Wong Education FoundationMacau Foundation for Development of Science and Technology 0008/2024/RIA1National Natural Science Foundation of China 22205079National Natural Science Foundation of China 82072470National Natural Science Foundation of China 82673199National Natural Science Foundation of China U24A6013National Science Fund for Distinguished Young Scholars 82225025Science and Technology Projects in Guangzhou 2024A03J0971Science and Technology Projects in Guangzhou 2024A04J6408Science and Technology Projects in Guangzhou 2025A03J4325Shenzhen Medical Research Fund B2502029State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University SKLBMDA-2024104
6 · The paper itself

Abstract

Osteoarthritis (OA) progression is driven by persistent synovial inflammation, amplified by oxidative stress and enhanced glycolysis. Our previous study has demonstrated that glucose transporter 1 (GLUT1) plays a key role in initiating OA synovitis via regulation of glycolysis. Single-cell RNA sequencing and tissue-specific fluorescent reporter mice (Prg4

Indexed as

glycolysismetabolic reprogrammingosteoarthritisredox homeostasisselenium nanoparticlessynovial inflammation

Identifiers

PMID42839644
PMCPMC13643119

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.