ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
A Hypothalamic Oxytocinergic-Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon-Bone Repair.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rotator cuff injury (RCI) is frequently accompanied by psychological comorbidities, particularly anxiety-related symptoms, which predict poor functional recovery, yet the central mechanisms linking affective disturbance to impaired tendon-bone healing remain unclear. Here, by integrating clinical neuroimaging, imaging transcriptomics, and mechanistic animal experiments, we identify hypothalamic paraventricular nucleus (PVN) oxytocinergic (OXT) neurons as a critical central node coordinating emotional regulation and bone-tendon interface (BTI) repair. In patients with RCI, resting-state fMRI (rs-fMRI) revealed reduced hypothalamic spontaneous activity that was inversely correlated with anxiety severity. Imaging transcriptomic analyses further linked these functional alterations to spatially concordant gene expression programs enriched in oxytocin signaling. In mouse models, retrograde viral tracing and spatial transcriptomics identified PVN
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