Observational studyBMC pulmonary medicine2026
Impact of pre-tracheostomy continuous enteral feeding on aspiration pneumonia risk and clinical outcomes: a prospective observational study.
Observational study in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07508293 (Impact of Pre-Tracheostomy Continuous Enteral Feeding on Aspiration Pneumonia Risk and Clinical Outcomes), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Impact of Pre-Tracheostomy Continuous Enteral Feeding on Aspiration Pneumonia Risk and Clinical Outcomes: A Prospective Observational Study
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe optimal management of enteral nutrition before tracheostomy in mechanically ventilated patients in the intensive care unit (ICU) remains uncertain, and pre-procedural fasting is widely practiced in clinical settings to reduce the risk of aspiration. However, interruption of enteral nutrition (EN) may adversely affect metabolic stability and caloric intake in critically ill patients. This study aimed to prospectively evaluate whether continuation of EN before tracheostomy increases aspiration risk or influences clinical outcomes in mechanically ventilated ICU patients. PATIENTS AND
methodsThis prospective observational study was conducted in the anesthesiology and resuscitation intensive care units of a tertiary care center. Adult mechanically ventilated patients scheduled for elective percutaneous tracheostomy were included. Patients were divided into two groups according to the enteral nutrition strategy applied before the procedure: the continuous feeding group and the fasting group. The primary endpoint was the incidence of aspiration pneumonia within 72 h after tracheostomy. Secondary endpoints included respiratory parameters, arterial blood gas measurements, delta (Δ) changes in physiological variables, procedure-related complications, and ICU and hospital outcomes.
resultsA total of 110 patients were assessed for eligibility, and 91 patients were included in the final analysis (continuous feeding group n = 45; fasting group n = 46). Baseline demographic characteristics, disease severity scores, and pre-tracheostomy respiratory parameters were comparable between groups. The incidence of aspiration pneumonia was 6.7% in the continuous feeding group and 4.4% in the fasting group, corresponding to an absolute risk difference of 2.3% (95% CI, - 6.6 to 11.2) and a crude odds ratio of 1.57 (95% CI, 0.25-9.88). Post-tracheostomy FiO
conclusionsContinuation of EN before tracheostomy with passive nasogastric drainage was not associated with a statistically significant increase in aspiration pneumonia or adverse outcomes compared with conventional fasting. However, the small number of events and wide confidence intervals indicate that clinically relevant differences cannot be excluded. Larger, adequately powered studies are needed to confirm safety and clarify the clinical implications of pre-tracheostomy feeding strategies.
trial registrationClinicalTrials.gov, NCT07508293. Registered on March 21, 2026, retrospectively registered.
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