Evidence map›Paper›PMID 42839196›Full record

ArticleJournal of community genetics2026

Negotiating genetic risk in Indonesia: Development and psychometric evaluation of the knowledge and attitude toward consanguineous marriage instrument in a mixed-methods cross-sectional study.

Ikramina Yusti Amina, Siti Zubaidah, Hendra Susanto

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Article in Journal of community genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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3 authors.

Ikramina Yusti AminaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia.
Siti ZubaidahDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia. siti.zubaidah.fmipa@um.ac.id.ORCID http://orcid.org/0000-0002-0718-6392
Hendra SusantoDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConsanguineous marriage can increase recessive genetic risks in offspring, yet instruments for examining genetic-risk understanding and attitudes remain limited in Indonesia. This study developed and evaluated a questionnaire assessing knowledge responses and attitudes toward consanguineous marriage in Kalimantan.

methodsIn a convergent mixed-methods cross-sectional survey, 272 respondents completed ten Yes/No knowledge items with written justifications and 15 Likert-type attitude statements. Knowledge responses were examined using Rasch modeling, attitude items using exploratory and confirmatory factor analyses, and written explanations using thematic analysis. Yes-response totals were compared by gender using an independent-samples t-test and a two-way analysis of variance with parental consanguinity status.

resultsKnowledge items showed stable relative item locations (item reliability = 0.98) but limited respondent differentiation (person reliability = 0.39). A ten-item, one-factor attitude model showed good fit (comparative fit index = 0.988; Tucker-Lewis index = 0.984; root mean square error of approximation = 0.047) and internal consistency (Cronbach's alpha = 0.816). Women selected more Yes responses than men (7.66 vs 7.10; p = 0.015), whereas the factorial gender main effect was not significant (p = 0.954). Written explanations combined genetic-risk reasoning with beliefs about destiny, taboo, and family expectations.

conclusionThe questionnaire provides preliminary psychometric evidence in the surveyed sample. Because the knowledge section combines factual statements, self-reported awareness, preventive endorsement, and hypothetical choice, its summed score should be interpreted as "yes-response" endorsement rather than a uniform count of scientifically correct answers. Further validation across populations and settings is warranted.

Indexed as

Confirmatory factor analysisConsanguineous marriageGenetic literacyIndonesiaKnowledge-attitude gapRasch modeling

Identifiers

PMID42839196
PMCPMC13642889

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.