ArticleCancer causes & control : CCC2026
Age- and latency-specific patterns of subsequent malignant brain and other nervous system tumors after cancer diagnosed before age 40 years.
Article in Cancer causes & control : CCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe age- and latency-specific patterns of excess incidence of malignant brain and other nervous system tumors after cancer diagnosed before age 40 years.
methodsWe studied first primary malignancies other than brain and other nervous system cancers in SEER 8 (1975-2023). Standardized incidence ratios (SIRs) compared observed with population-expected events across diagnosis age groups and latency intervals. A supplementary competing risk analysis estimated cumulative incidence.
resultsAmong 276,844 individuals contributing 3,970,462 person-years, 345 tumors occurred versus 236.97 expected (SIR, 1.46; 95% confidence interval [CI], 1.31-1.62; excess absolute risk [EAR], 2.72 per 100,000 person-years). SIRs were 5.20 at ages 0-14, 1.84 at 15-19, 1.17 at 20-29, and 1.23 at 30-39 years. Age patterns varied by latency (interaction p = .0012). At 10 or more years, the childhood SIR was 4.64 (95% CI, 3.22-6.49). The 20-year cumulative incidence after the 2-month landmark was 0.257% (95% CI, 0.193-0.341%) after childhood cancer.
conclusionIn this population-based descriptive analysis, childhood cancer survivors had the greatest relative excess incidence, which remained evident beyond 10 years. Absolute excess and cumulative incidence were small. Joint assessment of diagnosis age and latency characterized patterns obscured by the overall estimate.
Indexed as
Identifiers
42839191What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.