Evidence map›Paper›PMID 42839083›Full record

ArticleNature chemical biology2026

Cell-cycle-driven noncanonical ubiquitination of METTL14 orchestrates RNA methylation.

Jie Cao, Xiner Ying, Lili Zhou, Qingyi Zhang, Chenyang Huang, Tong Dai, Xiao Shu, Minsong Gao, Yujie Mi, Xiaojin Wu and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jie Cao *MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0001-9988-478X
Xiner Ying *MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.
Lili Zhou *The First Affiliated Hospital of Soochow University, Institutes of Biology and Medical Science, Suzhou Medical College, Soochow University, Suzhou, China.
Qingyi Zhang *MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0002-0932-1041
Chenyang HuangMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0009-0009-4028-112X
Tong DaiThe Children's Hospital, Institutes of Biology and Medical Science, Suzhou Medical College of Soochow University, Suzhou, China.
Xiao ShuMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0002-1053-1353
Minsong GaoMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0003-1734-112X
Yujie MiMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.
Xiaojin WuThe First Affiliated Hospital of Soochow University, Suzhou, China.ORCID http://orcid.org/0000-0003-3894-0631
Fengqin WangCollege of Animal Sciences, Key Laboratory of Animal Nutrition and Feed Sciences, Ministry of Agriculture, Zhejiang University, Hangzhou, China.
Long ZhangLife Sciences Institute and State Key Laboratory of Transvascular Implantation Devices of the Second Affiliated Hospital of the Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China. l_zhang@zju.edu.cn.ORCID http://orcid.org/0000-0001-8139-0474
Fangfang ZhouThe First Affiliated Hospital of Soochow University, Institutes of Biology and Medical Science, Suzhou Medical College, Soochow University, Suzhou, China. zhoufangfang@suda.edu.cn.ORCID http://orcid.org/0000-0003-1870-7584
Xin-Hua FengMOE Key Laboratory of Biosystems Homeostasis and Protection, Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China. xhfeng@zju.edu.cn.ORCID http://orcid.org/0000-0002-4418-0811
Jianzhao LiuMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China. liujz@zju.edu.cn.ORCID http://orcid.org/0000-0001-9465-6075

Funding

China Postdoctoral Science Foundation 2021M702844Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2022YFA1103702Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2022YFC3401500National Natural Science Foundation of China (National Science Foundation of China) 22477109National Natural Science Foundation of China (National Science Foundation of China) 32321002National Natural Science Foundation of China (National Science Foundation of China) 32525002National Natural Science Foundation of China (National Science Foundation of China) LD21C070001National Natural Science Foundation of China (National Science Foundation of China) W2531062
6 · The paper itself

Abstract

The precise temporal control of global mRNA methylation during the cell cycle is critical, yet the underlying mechanism remains unknown. Here we elucidate a noncanonical ubiquitination-mediated regulatory mechanism whereby RLIM deposits predominantly K27-linked ubiquitin (K27-Ub) on the m

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.