Articlenpj metabolic health and disease2026
The clock gene cycle synchronizes circadian metabolic oscillations uniquely in reproductively active Culex pipiens females.
Article in npj metabolic health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The circadian clock regulates changes in daily metabolite abundance, coordinating animal activity, feeding and rest. The Northern house mosquito, Culex pipiens, also displays seasonal changes between periods of reproductive activity and overwintering diapause, regulated by changes in daylength. However, differences in metabolic oscillations between diapause and non-diapause have yet to be characterized. We hypothesized that reproductively active, non-diapausing mosquitoes would show large metabolic oscillations compared to diapausing mosquitoes. Our previous work demonstrated that CYCLE regulates insulin signaling, reproductive growth and olfaction, and that knocking out cycle causes a diapause-like state regardless of photoperiod, thus we predicted large-scale disruptions to the daily and seasonal metabolomes of CpCyc
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.