Evidence map›Paper›PMID 42839026›Full record

ReviewEuropean journal of human genetics : EJHG2026

Health inequalities in precision medicine: A systematic review.

Zeinab M Hassanein, Manpreet Bains, Rupinder Kaur Bajwa, Jo Leonardi-Bee, Leah Jayes, Ilze Bogdanovica, Jeremiah Donoghue, Linda Amah, Patricia Egwumba, Fatimah Aiyelabegan and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in European journal of human genetics : EJHG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zeinab M HassaneinDepartment of Public Health and Community Medicine, Assiut University, Assiut, Egypt. zeinab_mostafa2015@aun.edu.eg.ORCID http://orcid.org/0000-0001-6141-7676
Manpreet BainsPRISM research group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.
Rupinder Kaur BajwaPRISM research group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.
Jo Leonardi-BeeCentre for Evidence Based Healthcare, School of Medicine, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0003-0893-6068
Leah JayesInstitute of Health and Allied Professions, Nottingham Trent University, Nottingham, UK.
Ilze BogdanovicaPRISM research group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.
Jeremiah DonoghueCentre for Evidence and Implementation science, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0009-0009-0066-509X
Linda AmahCentre for Evidence Based Healthcare, School of Medicine, University of Nottingham, Nottingham, UK.
Patricia EgwumbaCentre for Evidence Based Healthcare, School of Medicine, University of Nottingham, Nottingham, UK.
Fatimah AiyelabeganCentre for Evidence Based Healthcare, School of Medicine, University of Nottingham, Nottingham, UK.
Salah HassanPRISM research group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.
Nicola FletcherSchool of Medicine, University of Nottingham, Nottingham, UK.
Nadeem QureshiPRISM research group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, UK. nadeem.qureshi@nottingham.ac.uk.ORCID http://orcid.org/0000-0003-4909-0644

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision medicine aims to revolutionise healthcare by providing personalised treatments based on individual genetic variations. A systematic review was conducted to explore ethnic inequalities in precision medicine, focusing on representation of ethnic minorities or indigenous minority groups in the reporting of genomic research in any healthcare setting in the UK or other high-income countries with similar healthcare systems. Seven electronic databases (MEDLINE, EMBASE, PsycINFO, CINAHL, ProQuest Central, ASSIA and Scopus) were searched from inception to October 2022. Two authors independently screened papers, extracted data, and assessed quality. This review included 137 studies and a narrative synthesis was performed. The review included both genome-wide association studies (GWAS) and related studies of polygenic risk scores, and consistently identified that these studies failed to report or inadequately reported genomic results in certain ethnic minorities or indigenous minority groups. Downstream this compromises the value of this research to improve genomic services for multi-ethnic populations in High-income countries. This can be improved by purposefully recruiting participants from these underrepresented communities.Review registration: Registered with the International Prospective Register of Systematic Reviews (PROSPERO) in November 2022; ID: CRD42022371245.

Identifiers

PMID42839026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.