Evidence map›Paper›PMID 42839005›Full record

ReviewNature communications2026

Neuropsychiatry genetics in Africa.

Conrad O Iyegbe, Melek Chaouch, Itunuoluwa Isewon, Lerato Majara, Olatunde Ayinde, Michaela A O'Hare, Mary Mufford, Ofure A Ubah, Amine Larnaout, Anje-Lore Grobler and 17 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Conrad O IyegbeDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, USA. conrad.iyegbe@mssm.edu.ORCID 0000-0003-4908-5183
Melek ChaouchLaboratory of Bioinformatics, Biomathematics and Biostatistics-LR16IPT09, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID 0000-0001-5868-4204
Itunuoluwa IsewonDepartment of Computer & Information Sciences, Covenant University, Ota, Ogun State, Nigeria.ORCID 0000-0001-9653-8929
Lerato MajaraStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Olatunde AyindeDepartment of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Michaela A O'HareSouth African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Mary MuffordSouth African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-8409-9217
Ofure A UbahDepartment of Genes and Environment, Max Planck Institute for Psychiatry, Munich and Max Planck School of Cognition, Leipzig, Germany.ORCID 0000-0001-5409-7731
Amine LarnaoutDepartment of Psychiatry, Razi Hospital, Faculty of medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.
Anje-Lore GroblerSouth African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Matsepo RamaboliSouth African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-5295-5277
Nto J NtoSouth African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-9601-9870
Emmanuel AlagbeCovenant University Bioinformatics Research (CUBRe), Covenant University, Ota, Ogun State, Nigeria.ORCID 0000-0002-1072-0234
Sylvanus ToikumoDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.ORCID 0000-0002-6024-0693
Fatima ElmugadamNeurogenetics Research Group, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Celia van der MerweThe Stanley Centre for Psychiatric Research at the Broad Institute of Harvard and MIT, Boston, Massachusetts, USA.ORCID 0000-0003-0198-2184
Oye GurejeWorld Health Organization Collaborating Centre for Research and Training in Mental Health, Neurosciences and Substance Abuse, Department of Psychiatry, University of Ibadan, Ibadan, Nigeria.
Mounia BensaidLaboratory of Pathological Anatomy, Military Hospital Mohamed V, Rabat, Morocco.
Mohammed AbdulazizAfrica Centres for Disease Control and Prevention, Addis Ababa, Ethiopia.
Said BoujrafFaculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Alia BenkahlaLaboratory of Bioinformatics, Biomathematics and Biostatistics-LR16IPT09, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
Zané LombardDivision of Human Genetics, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0002-7997-2616
Soraya SeedatDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-5118-786X
Niran OkewoleDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1670-8516
Kenneth A Ae-NgbiseKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo, Ghana.ORCID 0000-0001-5638-4814
Sian Hemmings *South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-8461-1017
Aïcha Dahdouh *Department of Psychiatry, Service Hospitalo-Universitaire, Pôle 15. GHU Paris Psychiatrie & Neurosciences, Paris, France.

Funding

BridgePRS: bridging the gap in polygenic risk scores between ancestries.R01HG012773 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul Francis O'Reilly · 2023 to 2026
$2.6M
3/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124839 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ANDREASSEN, OLE A, HUCKINS, LAURA MARIANNE · 2021 to 2025
$2.0M
Broad Institute | Stanley Center for Psychiatric Research, Broad Institute (Stanley Center) NoneNHGRI NIH HHS R01 HG012773NIMH NIH HHS R01 MH124839U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) R01HG012773U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH124839
6 · The paper itself

Abstract

Across Africa, rising mental health needs coincide with rapid advances in genomics, digital health and continental policy reform. Yet research into the genetic, environmental and social determinants of neuropsychiatric illness remains sparse and underfunded. This review argues that African leadership in neuropsychiatric genetics can strengthen discovery, guide prevention and care, and support equitable precision public health, provided that investment in cohorts, informatics, governance and workforce development is sustained and scaled. By linking the advancement of genomics to health systems, biobanking and translational innovation, Africa can define globally-relevant models of inclusive mental health research, care and sustainable development.

Indexed as

Mental DisordersNeuropsychiatryAfricaGenomicsHumansMental Health

Identifiers

PMID42839005
PMCPMC13642932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.