Evidence map›Paper›PMID 42839001›Full record

ArticleMolecular psychiatry2026

Association between polygenic liability to depression and lifetime depression in at-risk adolescents.

Enda M Byrne, Nathan A Gillespie, Jake M Najman, Anjali K Henders, Brittany L Mitchell, Dominic Dwyer, Simon Hartmann, Blake S Cavve, G Paul Amminger, Scott Clark and 17 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Enda M ByrneChild Health Research Centre, The University of Queensland, Brisbane, Australia. enda.byrne@uq.edu.au.ORCID http://orcid.org/0000-0002-9491-7797
Nathan A GillespieVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0001-8655-2823
Jake M NajmanSchool of Public Health, The University of Queensland, Brisbane, Australia.
Anjali K HendersInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Brittany L MitchellQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID http://orcid.org/0000-0002-9050-1516
Dominic DwyerOrygen, Melbourne, Australia.ORCID http://orcid.org/0000-0003-3949-5867
Simon HartmannAdelaide Medical School, Discipline of Psychiatry, The University of Adelaide, Adelaide, Australia.ORCID http://orcid.org/0000-0001-9689-0594
Blake S CavveTelethon Kids Institute, The University of Western Australia, Perth, Australia.
G Paul AmmingerOrygen, Melbourne, Australia.
Scott ClarkAdelaide Medical School, Discipline of Psychiatry, The University of Adelaide, Adelaide, Australia.ORCID http://orcid.org/0000-0003-1640-5611
Caroline GaoOrygen, Melbourne, Australia.
Ashleigh LinTelethon Kids Institute, The University of Western Australia, Perth, Australia.
Lianne SchmaalOrygen, Melbourne, Australia.
Andrew ThompsonOrygen, Melbourne, Australia.
Stephen J WoodOrygen, Melbourne, Australia.ORCID http://orcid.org/0000-0003-4186-5919
J T W WigmanDepartment of Psychiatry, Interdisciplinary Center for Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Alison R YungOrygen, Melbourne, Australia.ORCID http://orcid.org/0000-0002-0401-9791
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID http://orcid.org/0000-0003-1382-380X
Jacob J CrouseYouth Mental and Technology Health Team, Brain & Mind Centre, The University of Sydney, Camperdown, Australia.ORCID http://orcid.org/0000-0002-3805-2936
Jan ScottDepartment of Academic Psychiatry, Institute of Neuroscience, Newcastle University, Newcastle, England.ORCID http://orcid.org/0000-0002-7203-8601
James G ScottChild Health Research Centre, The University of Queensland, Brisbane, Australia.
Gail M WilliamsSchool of Public Health, The University of Queensland, Brisbane, Australia.
Barnaby NelsonOrygen, Melbourne, Australia.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Ian B HickieYouth Mental and Technology Health Team, Brain & Mind Centre, The University of Sydney, Camperdown, Australia.ORCID http://orcid.org/0000-0001-8832-9895
Naomi R WrayInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID http://orcid.org/0000-0001-7421-3357
Christel M MiddeldorpChild Health Research Centre, The University of Queensland, Brisbane, Australia.

Funding

Department of Health | National Health and Medical Research Council (NHMRC) 1198304
6 · The paper itself

Abstract

Internalising symptoms including depression, anxiety and somatic symptoms in adolescence are common. They can be transient, but they can also persist and progress to major depressive disorder (MDD) Polygenic risk scores for major depression (MD-PGS) may help identify which symptomatic adolescents are at greatest risk of later disorder. In a mega-analysis of two longitudinal population-based cohorts from Brisbane, Australia, we investigated whether polygenic liability to depression improves risk stratification among adolescents with elevated internalising symptoms. Internalising symptoms were assessed at age 14, lifetime MDD was assessed in young adulthood using the Composite International Diagnostic Interview, and MD-PGS were generated using summary statistics from the latest Psychiatric Genomics Consortium major depression genome-wide association study, excluding Australian cohorts. Analyses focused on comparisons between individuals in the top decile of risk and those in the remaining 90% of each cohort. A total of 302 cases with lifetime MDD and 1693 controls were included. Compared with adolescents outside the highest decile of internalising symptoms, those in the top decile at age 14 had a more than two-fold increased odds of lifetime MDD (OR = 2.56, 95% CI 1.92-3.49, p = 5.4 × 10

Identifiers

PMID42839001

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.