Evidence map›Paper›PMID 42838951›Full record

ArticleCell death & disease2026

Mycobacterium tuberculosis infects human peripheral hematopoietic multipotent progenitors and promotes their myeloid differentiation in vitro.

Tonino Alonzi, Daniela Peruzzu, Alessandra Aiello, Giulio Bontempi, Chiara Farroni, Federica Repele, Settimia Sbarra, Valentina Vanini, Ivana Palucci, Michela Sali and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tonino Alonzi *Translational Research Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, Rome, Italy.
Daniela Peruzzu *Translational Research Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, Rome, Italy.
Alessandra Aiello *Translational Research Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, Rome, Italy.
Giulio BontempiDepartment of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases IRCCS "Lazzaro Spallanzani", Rome, Italy.
Chiara FarroniTranslational Research Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, Rome, Italy.
Federica RepeleTranslational Research Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, Rome, Italy.
Settimia SbarraTranslational Research Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, Rome, Italy.
Valentina VaniniTranslational Research Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, Rome, Italy.
Ivana PalucciDipartimento di Scienze Biotecnologiche di base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
Michela SaliDipartimento di Scienze Biotecnologiche di base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
Luca PierelliTransfusion Medicine Unit, San Camillo Forlanini Hospital, Rome, Italy.
Raffaele StrippoliDepartment of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases IRCCS "Lazzaro Spallanzani", Rome, Italy.ORCID http://orcid.org/0000-0003-3483-8381
Giovanni DeloguDepartment of Medicine and Surgery, University of Parma, Parma, Italy.ORCID http://orcid.org/0000-0003-0182-8267
Delia GolettiTranslational Research Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, Rome, Italy. delia.goletti@inmi.it.ORCID http://orcid.org/0000-0001-8360-4376

Funding

Ministero della Salute (Ministry of Health, Italy) Ricerca Corrente Linea 4 (Progetto n.2)
6 · The paper itself

Abstract

Mycobacterium tuberculosis (Mtb) persists as a global health threat partly by establishing long-term reservoirs in myeloid cells. Although progenitors have been proposed as additional sites of persistence and immune reprogramming, it remains unclear whether circulating human hematopoietic stem/progenitor cells (HSPC) are permissive to Mtb infection. Here, we show that peripheral blood-derived CD34

Indexed as

Cell DifferentiationHematopoietic Stem CellsMultipotent Stem CellsMycobacterium tuberculosisMyeloid CellsTuberculosisAntigens, CD34HumansInterleukin-8Mycobacterium bovisTumor Necrosis Factor-alphaAntigens, CD34Interleukin-8Tumor Necrosis Factor-alpha

Identifiers

PMID42838951
PMCPMC13642923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.